Soft tissue sarcomas with complex genomic profiles.

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Serval ID
serval:BIB_04F69B85DB88
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Soft tissue sarcomas with complex genomic profiles.
Journal
Virchows Archiv
Author(s)
Guillou Louis, Aurias Alain
ISSN
1432-2307[electronic], 0945-6317[linking]
Publication state
Published
Issued date
2010
Volume
456
Number
2
Pages
201-217
Language
english
Abstract
Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurrent aberrations (e.g., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination. In this paper, we review the cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles. Features of diagnostic or prognostic relevance will be discussed when needed.
Keywords
Soft tissue Sarcoma, Karyotype, Genetics, Nerve Sheath Tumors, Malignant Fibrous Histiocytoma, Myxoinflammatory Fibroblastic Sarcoma, Dna Copy Number, Smooth-Muscle Tumors, Champ Study-Group, Mesenchymal Progenitor Cells, Gene-Expression Analysis, Of-The-Literature, Pleomorphic Liposarcoma
Pubmed
Web of science
Open Access
Yes
Create date
16/03/2010 12:02
Last modification date
01/10/2019 7:16
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