Identifying the neural correlates of executive functions in early cerebral microangiopathy: a combined VBM and DTI study.

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Serval ID
serval:BIB_04CDCEFE9B9E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Identifying the neural correlates of executive functions in early cerebral microangiopathy: a combined VBM and DTI study.
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Quinque E.M., Arélin K., Dukart J., Roggenhofer E., Streitbuerger D.P., Villringer A., Frisch S., Mueller K., Schroeter M.L.
ISSN
1559-7016 (Electronic)
ISSN-L
0271-678X
Publication state
Published
Issued date
2012
Volume
32
Number
10
Pages
1869-1878
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Cerebral microangiopathy (CMA) has been associated with executive dysfunction and fronto-parietal neural network disruption. Advances in magnetic resonance imaging allow more detailed analyses of gray (e.g., voxel-based morphometry-VBM) and white matter (e.g., diffusion tensor imaging-DTI) than traditional visual rating scales. The current study investigated patients with early CMA and healthy control subjects with all three approaches. Neuropsychological assessment focused on executive functions, the cognitive domain most discussed in CMA. The DTI and age-related white matter changes rating scales revealed convergent results showing widespread white matter changes in early CMA. Correlations were found in frontal and parietal areas exclusively with speeded, but not with speed-corrected executive measures. The VBM analyses showed reduced gray matter in frontal areas. All three approaches confirmed the hypothesized fronto-parietal network disruption in early CMA. Innovative methods (DTI) converged with results from conventional methods (visual rating) while allowing greater spatial and tissue accuracy. They are thus valid additions to the analysis of neural correlates of cognitive dysfunction. We found a clear distinction between speeded and nonspeeded executive measures in relationship to imaging parameters. Cognitive slowing is related to disease severity in early CMA and therefore important for early diagnostics.
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Web of science
Create date
01/11/2012 18:32
Last modification date
20/08/2019 12:26
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