Identifying the neural correlates of executive functions in early cerebral microangiopathy: a combined VBM and DTI study.

Détails

Ressource 1Télécharger: BIB_04CDCEFE9B9E.P001.pdf (560.22 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_04CDCEFE9B9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Identifying the neural correlates of executive functions in early cerebral microangiopathy: a combined VBM and DTI study.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur⸱e⸱s
Quinque E.M., Arélin K., Dukart J., Roggenhofer E., Streitbuerger D.P., Villringer A., Frisch S., Mueller K., Schroeter M.L.
ISSN
1559-7016 (Electronic)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
2012
Volume
32
Numéro
10
Pages
1869-1878
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Cerebral microangiopathy (CMA) has been associated with executive dysfunction and fronto-parietal neural network disruption. Advances in magnetic resonance imaging allow more detailed analyses of gray (e.g., voxel-based morphometry-VBM) and white matter (e.g., diffusion tensor imaging-DTI) than traditional visual rating scales. The current study investigated patients with early CMA and healthy control subjects with all three approaches. Neuropsychological assessment focused on executive functions, the cognitive domain most discussed in CMA. The DTI and age-related white matter changes rating scales revealed convergent results showing widespread white matter changes in early CMA. Correlations were found in frontal and parietal areas exclusively with speeded, but not with speed-corrected executive measures. The VBM analyses showed reduced gray matter in frontal areas. All three approaches confirmed the hypothesized fronto-parietal network disruption in early CMA. Innovative methods (DTI) converged with results from conventional methods (visual rating) while allowing greater spatial and tissue accuracy. They are thus valid additions to the analysis of neural correlates of cognitive dysfunction. We found a clear distinction between speeded and nonspeeded executive measures in relationship to imaging parameters. Cognitive slowing is related to disease severity in early CMA and therefore important for early diagnostics.
Pubmed
Web of science
Création de la notice
01/11/2012 18:32
Dernière modification de la notice
20/08/2019 12:26
Données d'usage