Heterogeneity in Obesity: Genetic Basis and Metabolic Consequences.

Details

Serval ID
serval:BIB_04472A5564DF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Heterogeneity in Obesity: Genetic Basis and Metabolic Consequences.
Journal
Current diabetes reports
Author(s)
Sulc J., Winkler T.W., Heid I.M., Kutalik Z.
ISSN
1539-0829 (Electronic)
ISSN-L
1534-4827
Publication state
Published
Issued date
22/01/2020
Peer-reviewed
Oui
Volume
20
Number
1
Pages
1
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
Our review provides a brief summary of the most recent advances towards the identification of the genetic basis of specific aspects of obesity and the quantification of their consequences on health. We also highlight the most promising avenues to be explored in the future.
While obesity has been demonstrated to lead to adverse cardio-metabolic consequences, the determinants of inter-individual variability remain largely unknown. The elucidation of the molecular underpinnings of this relationship is hampered by the extremely heterogeneous nature of obesity as a human trait. Recent technological advances have facilitated a more in-depth characterization of body composition at large-scale. At the pace of current data acquisition and resolution, it is realistic to improve characterization of obesity and to advise individuals based on detailed body composition combined with tissue-specific molecular signatures. Individualized predictions of health implications would enable more personalized and effective public health interventions.
Keywords
Adiposity/genetics, Adiposity/physiology, Body Composition/genetics, Body Composition/physiology, Body Fat Distribution, Body Mass Index, Genetic Heterogeneity, Humans, Obesity/complications, Obesity/diagnosis, Obesity/genetics, Obesity/metabolism, Phenotype, Sex Factors, Waist Circumference/genetics, Waist Circumference/physiology, GWAS, Mendelian randomization, Metabolic disease, Obesity genetics, Obesity subtypes
Pubmed
Web of science
Create date
29/01/2020 17:01
Last modification date
18/08/2020 5:21
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