Heterogeneity in Obesity: Genetic Basis and Metabolic Consequences.

Détails

ID Serval
serval:BIB_04472A5564DF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Heterogeneity in Obesity: Genetic Basis and Metabolic Consequences.
Périodique
Current diabetes reports
Auteur⸱e⸱s
Sulc J., Winkler T.W., Heid I.M., Kutalik Z.
ISSN
1539-0829 (Electronic)
ISSN-L
1534-4827
Statut éditorial
Publié
Date de publication
22/01/2020
Peer-reviewed
Oui
Volume
20
Numéro
1
Pages
1
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Résumé
Our review provides a brief summary of the most recent advances towards the identification of the genetic basis of specific aspects of obesity and the quantification of their consequences on health. We also highlight the most promising avenues to be explored in the future.
While obesity has been demonstrated to lead to adverse cardio-metabolic consequences, the determinants of inter-individual variability remain largely unknown. The elucidation of the molecular underpinnings of this relationship is hampered by the extremely heterogeneous nature of obesity as a human trait. Recent technological advances have facilitated a more in-depth characterization of body composition at large-scale. At the pace of current data acquisition and resolution, it is realistic to improve characterization of obesity and to advise individuals based on detailed body composition combined with tissue-specific molecular signatures. Individualized predictions of health implications would enable more personalized and effective public health interventions.
Mots-clé
Adiposity/genetics, Adiposity/physiology, Body Composition/genetics, Body Composition/physiology, Body Fat Distribution, Body Mass Index, Genetic Heterogeneity, Humans, Obesity/complications, Obesity/diagnosis, Obesity/genetics, Obesity/metabolism, Phenotype, Sex Factors, Waist Circumference/genetics, Waist Circumference/physiology, GWAS, Mendelian randomization, Metabolic disease, Obesity genetics, Obesity subtypes
Pubmed
Web of science
Création de la notice
29/01/2020 17:01
Dernière modification de la notice
18/08/2020 5:21
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