Assessing Pseudomonas aeruginosa Persister/antibiotic tolerant cells.

Details

Serval ID
serval:BIB_03FD913C231C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Assessing Pseudomonas aeruginosa Persister/antibiotic tolerant cells.
Journal
Methods in Molecular Biology
Author(s)
Hazan R., Maura D., Que Y.A., Rahme L.G.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
1149
Pages
699-707
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural Publication Status: ppublish
Abstract
Bacterial persistence, which is observed in a broad range of microbial species, is the capacity of a bacterial cell subpopulation called "persisters" to tolerate exposure to normally lethal concentrations of bactericidal antibiotics. This ability, which is not due to antibiotic-resistant mutants, has been implicated in antibiotic treatment failures and may account for latent, chronic, and relapsing infections. Antibiotic tolerant/Persister (AT/P) cells have been notoriously difficult to study due to their low frequency and transient nature. This chapter describes the main methods used to isolate and study Pseudomonas aeruginosa AT/P cells and discusses new technologies that may ease research of P. aeruginosa persisters in the near future.
Pubmed
Web of science
Create date
28/10/2014 9:08
Last modification date
20/08/2019 12:25
Usage data