Cancer: Linking Powerhouses to Suicidal Bags.

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State: Serval
Version: Final published version
Serval ID
serval:BIB_030409EABA61
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Cancer: Linking Powerhouses to Suicidal Bags.
Journal
Frontiers in Oncology
Author(s)
Martinez-Carreres L., Nasrallah A., Fajas L.
ISSN
2234-943X (Print)
ISSN-L
2234-943X
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
7
Pages
204
Language
english
Abstract
Membrane-bound organelles are integrated into cellular networks and work together for a common goal: regulating cell metabolism, cell signaling pathways, cell fate, cellular maintenance, and pathogen defense. Many of these interactions are well established, but little is known about the interplay between mitochondria and lysosomes, and their deregulation in cancer. The present review focuses on the common signaling pathways of both organelles, as well as the processes in which they both physically interact, their changes under pathological conditions, and the impact on targeting those organelles for treating cancer.

Keywords
AMP-activated protein kinase, Rab7, cancer, lysosomal membrane permeabilization, lysosomes, mammalian target of rapamycin, mitochondria, mitophagy
Pubmed
Web of science
Open Access
Yes
Create date
09/10/2017 10:30
Last modification date
08/05/2019 13:47
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