Toward an understanding of the correlates of protective immunity to HIV infection

Details

Serval ID
serval:BIB_0273EF843115
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Toward an understanding of the correlates of protective immunity to HIV infection
Journal
Science
Author(s)
Haynes  B. F., Pantaleo  G., Fauci  A. S.
ISSN
0036-8075 (Print)
Publication state
Published
Issued date
01/1996
Volume
271
Number
5247
Pages
324-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Jan 19
Abstract
Considerable progress has been made recently in understanding the genetic, immunologic and virologic factors in human immunodeficiency virus (HIV)-infected individuals who either rapidly progress or do not progress to acquired immunodeficiency syndrome (AIDS). In addition, detection of HIV-specific immune responses in HIV-negative individuals who have been exposed to the virus multiple times suggests that natural immune responses to HIV may be protective in rare individuals. Understanding the correlates of protective immunity to HIV infection is critical to efforts to develop preventive HIV vaccines as well as to determine the feasibility of treating HIV infection by boosting immunity to HIV.
Keywords
AIDS Vaccines Acquired Immunodeficiency Syndrome/*immunology/virology Animals CD4-Positive T-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Cytokines/immunology Disease Progression HIV/immunology/physiology HIV Antibodies/*immunology HIV Infections/*immunology/virology HIV Seronegativity/immunology Humans Major Histocompatibility Complex T-Lymphocytes/*immunology Virus Replication
Pubmed
Web of science
Create date
25/01/2008 15:14
Last modification date
20/08/2019 12:24
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