Rational design of an organometallic glutathione transferase inhibitor.

Details

Serval ID
serval:BIB_0133BD089CFC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Rational design of an organometallic glutathione transferase inhibitor.
Journal
Angewandte Chemie
Author(s)
Ang W.H., Parker L.J., De Luca A., Juillerat-Jeanneret L., Morton C.J., Lo Bello M., Parker M.W., Dyson P.J.
ISSN
1521-3773[electronic]
Publication state
Published
Issued date
2009
Volume
48
Number
21
Pages
3854-3857
Language
english
Abstract
Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.
Pubmed
Web of science
Create date
18/05/2009 18:22
Last modification date
20/08/2019 13:23
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