Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia.

Details

Serval ID
serval:BIB_012EAAA6447D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia.
Journal
Neurobiology of disease
Author(s)
Cabungcal J.H., Nicolas D., Kraftsik R., Cuénod M., Do K.Q., Hornung J.P.
ISSN
0969-9961
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
22
Number
3
Pages
624-37
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
A series of studies in schizophrenic patients report a decrease of glutathione (GSH) in prefrontal cortex (PFC) and cerebrospinal fluid, a decrease in mRNA levels for two GSH synthesizing enzymes and a deficit in parvalbumin (PV) expression in a subclass of GABA neurons in PFC. GSH is an important redox regulator, and its deficit could be responsible for cortical anomalies, particularly in regions rich in dopamine innervation. We tested in an animal model if redox imbalance (GSH deficit and excess extracellular dopamine) during postnatal development would affect PV-expressing neurons. Three populations of interneurons immunolabeled for calcium-binding proteins were analyzed quantitatively in 16-day-old rat brain sections. Treated rats showed specific reduction in parvalbumin immunoreactivity in the anterior cingulate cortex, but not for calbindin and calretinin. These results provide experimental evidence for the critical role of redox regulation in cortical development and validate this animal model used in schizophrenia research.
Keywords
Animals, Brain Chemistry, Calcium-Binding Protein, Vitamin D-Dependent, Disease Models, Animal, Dopamine, Extracellular Fluid, Glutathione, Immunohistochemistry, Male, Neurons, Parvalbumins, Prefrontal Cortex, Rats, Schizophrenia, gamma-Aminobutyric Acid
Pubmed
Web of science
Create date
10/03/2008 11:49
Last modification date
03/03/2018 13:14
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