Notch1 and T-cell development: insights from conditional knockout mice.

Details

Serval ID
serval:BIB_012B2C9E803D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Notch1 and T-cell development: insights from conditional knockout mice.
Journal
Trends in immunology
Author(s)
MacDonald H.R., Wilson A., Radtke F.
ISSN
1471-4906
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
22
Number
3
Pages
155-160
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.
Keywords
Animals, B-Lymphocytes/cytology, B-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/cytology, Cell Differentiation, Cell Lineage, Membrane Proteins/genetics, Membrane Proteins/physiology, Mice, Mice, Knockout, Receptor, Notch1, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Cell Surface, Signal Transduction/physiology, T-Lymphocytes/cytology, T-Lymphocytes/immunology, Transcription Factors
Pubmed
Web of science
Create date
28/01/2008 11:39
Last modification date
20/08/2019 12:23
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