Primary focal prostate radiotherapy: Do all patients really need whole-prostate irradiation?

Details

Serval ID
serval:BIB_00F99FD62C6A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Primary focal prostate radiotherapy: Do all patients really need whole-prostate irradiation?
Journal
Critical reviews in oncology/hematology
Author(s)
Jereczek-Fossa B.A., Ciardo D., Petralia G., Bellomi M., De Bari B., De Cobelli O., Orecchia R.
ISSN
1879-0461 (Electronic)
ISSN-L
1040-8428
Publication state
Published
Issued date
09/2016
Peer-reviewed
Oui
Volume
105
Pages
100-111
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
To review the available data about focal primary partial prostate irradiation (focal radiotherapy, FRT) for early prostate cancer.
Medline search for English language full paper on primary FRT for early prostate cancer including review articles, planning studies or patient series (clinical outcome available) published before May 31, 2015.
22 papers have been found: 11 review articles, 4 planning studies and 7 patient series. Eleven review articles were dedicated to all types of focal therapy including FRT and 2 to FRT only. All planning studies included brachytherapy and showed excellent organ-at-risk sparing. Patient series included together 715 patients (99% treated with brachytherapy) and showed promising tumour control in low-risk cancer. In intermediate-risk tumours, FRT might be suboptimal.
Primary FRT is feasible in early prostate cancer. As any other focal therapy, FRT remains investigational until numerous questions are answered.

Keywords
Brachytherapy, Clinical Trials as Topic, Humans, Male, Prostatic Neoplasms/diagnosis, Prostatic Neoplasms/radiotherapy
Pubmed
Create date
19/07/2016 17:41
Last modification date
20/08/2019 12:23
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