The regulatory network behind MHC class I expression.

Details

Serval ID
serval:BIB_00A3C095CDAC
Type
Article: article from journal or magazin.
Collection
Publications
Title
The regulatory network behind MHC class I expression.
Journal
Molecular immunology
Author(s)
Jongsma MLM, Guarda G., Spaapen R.M.
ISSN
1872-9142 (Electronic)
ISSN-L
0161-5890
Publication state
Published
Issued date
09/2019
Peer-reviewed
Oui
Volume
113
Pages
16-21
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is hijacked in many pathological conditions. This affects MHC class I levels and peptide presentation at the cell surface leading to immune escape of cancer cells or microbes. It is therefore important to identify the molecular mechanisms behind MHC class I expression, processing and antigen presentation. The identification of NLRC5 as regulator of MHC class I transcription was a huge step forward in understanding the transcriptional mechanism involved. Nevertheless, many questions concerning MHC class I transcription are yet unsolved. Here we illuminate current knowledge on MHC class I and NLRC5 transcription, we highlight some remaining questions and discuss the use of quickly developing high-content screening tools to reveal unknowns in MHC class I transcription in the near future.
Keywords
Animals, Antigen Presentation/genetics, Gene Regulatory Networks/genetics, Genes, MHC Class I/genetics, Humans, Intracellular Signaling Peptides and Proteins/genetics, Transcription, Genetic/genetics, Expression, MHC class I, NLRC5, Regulation, Screen, Transcription
Pubmed
Web of science
Open Access
Yes
Create date
14/12/2017 18:44
Last modification date
24/01/2020 7:19
Usage data