The regulatory network behind MHC class I expression.

Détails

ID Serval
serval:BIB_00A3C095CDAC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The regulatory network behind MHC class I expression.
Périodique
Molecular immunology
Auteur(s)
Jongsma MLM, Guarda G., Spaapen R.M.
ISSN
1872-9142 (Electronic)
ISSN-L
0161-5890
Statut éditorial
Publié
Date de publication
09/2019
Peer-reviewed
Oui
Volume
113
Pages
16-21
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is hijacked in many pathological conditions. This affects MHC class I levels and peptide presentation at the cell surface leading to immune escape of cancer cells or microbes. It is therefore important to identify the molecular mechanisms behind MHC class I expression, processing and antigen presentation. The identification of NLRC5 as regulator of MHC class I transcription was a huge step forward in understanding the transcriptional mechanism involved. Nevertheless, many questions concerning MHC class I transcription are yet unsolved. Here we illuminate current knowledge on MHC class I and NLRC5 transcription, we highlight some remaining questions and discuss the use of quickly developing high-content screening tools to reveal unknowns in MHC class I transcription in the near future.
Mots-clé
Expression, MHC class I, NLRC5, Regulation, Screen, Transcription
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/12/2017 17:44
Dernière modification de la notice
28/10/2019 6:09
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