Diagnostic d'embolie pulmonaire: problématique résiduelle des D-dimères faussement positifs [The unresolved issue of false-positive D-dimer results in the diagnostic workup of pulmonary embolism].

Details

Serval ID
serval:BIB_007533D12DEF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diagnostic d'embolie pulmonaire: problématique résiduelle des D-dimères faussement positifs [The unresolved issue of false-positive D-dimer results in the diagnostic workup of pulmonary embolism].
Journal
Revue Médicale Suisse
Author(s)
Hugli O., Aujesky D.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
08/2011
Volume
7
Number
305
Pages
1588-1592
Language
french
Notes
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish
Abstract
The unresolved issue of false-positive D-dimer results in the diagnostic workup of pulmonary embolism Pulmonary embolism (PE) remains a difficult diagnosis as it lacks specific symptoms and clinical signs. After the determination of the pretest PE probability by a validated clinical score, D-dimers (DD) is the initial blood test in the majority of patients whose probability is low or intermediate. The low specificity of DD results in a high number of false-positives that then require thoracic angio-CT. A new clinical decision rule, called the Pulmonary Embolism Rule-out criteria (PERC), identifies patients at such low risk that PE can be safely ruled-out without a DD test. Its safety has been confirmed in US emergency departments, but retrospective European studies showed that it would lead to 5-7% of undiagnosed PE. Alternative strategies are needed to reduce the proportion of false-positive DD results.
Keywords
Algorithms, Antifibrinolytic Agents/analysis, Biological Markers/analysis, Diagnosis, Differential, Fibrin Fibrinogen Degradation Products/analysis, Humans, Predictive Value of Tests, Pulmonary Embolism/diagnosis, Sensitivity and Specificity
Pubmed
Create date
18/01/2012 16:01
Last modification date
20/08/2019 12:22
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