The role of Notch in the differentiation of CD4⁺ T helper cells.

Details

Serval ID
serval:BIB_002AEA625D37
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The role of Notch in the differentiation of CD4⁺ T helper cells.
Journal
Current Topics in Microbiology and Immunology
Author(s)
Auderset F., Coutaz M., Tacchini-Cottier F.
ISSN
0070-217X (Print)
ISSN-L
0070-217X
Publication state
Published
Issued date
2012
Volume
360
Pages
115-134
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
CD4⁺ T helper cells are playing critical roles in host defense to pathogens and in the maintenance of immune homeostasis. Naïve CD4⁺T cells, upon antigen-specific recognition, receive signals to differentiate into distinct effector T helper cell subsets characterized by their pattern of cytokine production and specific immune functions. A tight balance between these different subsets ensures proper control of the immune response. There is increasing evidence revealing an important role for Notch signaling in the regulation of CD4⁺T helper cell differentiation or function in the periphery. However, the exact mechanisms involved remain unclear and appear contradictory. In this review, we summarize current knowledge and discuss recent advances in the field to reconcile different views on the role of Notch signaling in the differentiation of functional T helper subsets.
Pubmed
Web of science
Create date
19/12/2012 11:56
Last modification date
20/08/2019 13:22
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