serval:BIB_FF946CC0ABE7
Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons.
10.1093/cid/cit196
000320923700017
23532479
Rotger
M.
author
Glass
T.R.
author
Junier
T.
author
Lundgren
J.
author
Neaton
J.D.
author
Poloni
E.S.
author
van 't Wout
A.B.
author
Lubomirov
R.
author
Colombo
S.
author
Martinez
R.
author
Rauch
A.
author
Günthard
H.F.
author
Neuhaus
J.
author
Wentworth
D.
author
van Manen
D.
author
Gras
L.A.
author
Schuitemaker
H.
author
Albini
L.
author
Torti
C.
author
Jacobson
L.P.
author
Li
X.
author
Kingsley
L.A.
author
Carli
F.
author
Guaraldi
G.
author
Ford
E.S.
author
Sereti
I.
author
Hadigan
C.
author
Martinez
E.
author
Arnedo
M.
author
Egaña-Gorroño
L.
author
Gatell
J.M.
author
Law
M.
author
Bendall
C.
author
Petoumenos
K.
author
Rockstroh
J.
author
Wasmuth
J.C.
author
Kabamba
K.
author
Delforge
M.
author
De Wit
S.
author
Berger
F.
author
Mauss
S.
author
de Paz Sierra
M.
author
Losso
M.
author
Belloso
W.H.
author
Leyes
M.
author
Campins
A.
author
Mondi
A.
author
De Luca
A.
author
Bernardino
I.
author
Barriuso-Iglesias
M.
author
Torrecilla-Rodriguez
A.
author
Gonzalez-Garcia
J.
author
Arribas
J.R.
author
Fanti
I.
author
Gel
S.
author
Puig
J.
author
Negredo
E.
author
Gutierrez
M.
author
Domingo
P.
author
Fischer
J.
author
Fätkenheuer
G.
author
Alonso-Villaverde
C.
author
Macken
A.
author
Woo
J.
author
McGinty
T.
author
Mallon
P.
author
Mangili
A.
author
Skinner
S.
author
Wanke
C.A.
author
Reiss
P.
author
Weber
R.
author
Bucher
H.C.
author
Fellay
J.
author
Telenti
A.
author
Tarr
P.E.
author
MAGNIFICENT Consortium
contributor
INSIGHT
author
Swiss HIV Cohort Study
contributor
INSIGHT
contributor
Rotger
M.
contributor
Glass
TR.
contributor
Lubomirov
R.
contributor
Bucher
HC.
contributor
Telenti
A.
contributor
Tarr
PE.
contributor
Junier
T.
contributor
Poloni
ES.
contributor
Fellay
J.
contributor
Glass
TR.
contributor
Colombo
S.
contributor
Lubomirov
R.
contributor
Martinez
R.
contributor
Rotger
M.
contributor
Rauch
A.
contributor
Weber
R.
contributor
Günthard
HF.
contributor
Bucher
HC.
contributor
Fellay
J.
contributor
Telenti
A.
contributor
Tarr
PE.
contributor
Neuhaus
J.
contributor
Wentworth
D.
contributor
Lundgren
J.
contributor
Neaton
JD.
contributor
van Manen
D.
contributor
Gras
AL.
contributor
Schuitemaker
H.
contributor
van Wout AB.
contributor
Reiss
P.
contributor
Albini
L.
contributor
Torti
C.
contributor
Jacobson
LP.
contributor
Li
X.
contributor
Kingsley
LA.
contributor
Carli
F.
contributor
Guaraldi
G.
contributor
Ford
ES.
contributor
Sereti
I.
contributor
Hadigan
C.
contributor
Martinez
E.
contributor
Arnedo-Valero
M.
contributor
Egaña-Gorroño
L.
contributor
Gatell
JM.
contributor
Law
M.
contributor
Bendall
C.
contributor
Petoumenos
K.
contributor
Rockstroh
J.
contributor
Wasmuth
JC.
contributor
Kabamba
K.
contributor
Delforge
M.
contributor
De Wit
S.
contributor
Berger
F.
contributor
Mauss
S.
contributor
Sierra Mde
P.
contributor
Losso
M.
contributor
Belloso
WH.
contributor
Leyes
M.
contributor
Campins
A.
contributor
Mondi
A.
contributor
De Luca
A.
contributor
Bernardino
I.
contributor
Barriuso-Iglesias£££Mónica£££ M.
contributor
Rodriguez
AT.
contributor
Garcia
JG.
contributor
Arribas
JR.
contributor
Fanti
I.
contributor
De Luca
A.
contributor
Gel
S.
contributor
Puig
J.
contributor
Negredo
E.
contributor
Gutierrez
M.
contributor
Domingo
P.
contributor
Fischer
J.
contributor
Fätkenheuer
G.
contributor
Alonso-Villaverde
C.
contributor
Macken
A.
contributor
Woo
J.
contributor
McGinty
T.
contributor
Mallon
P.
contributor
Mangili
A.
contributor
Skinner
S.
contributor
Wanke
CA.
contributor
Aubert
V.
contributor
Barth
J.
contributor
Battegay
M.
contributor
Bernasconi
E.
contributor
Böni
J.
contributor
Bucher
HC.
contributor
Burton-Jeangros
C.
contributor
Calmy
A.
contributor
Cavassini
M.
contributor
Egger
M.
contributor
Elzi
L.
contributor
Fehr
J.
contributor
Fellay
J.
contributor
Francioli
P.
contributor
Furrer
H.
contributor
Fux
CA.
contributor
Gorgievski
M.
contributor
Günthard
H.
contributor
Haerry
D.
contributor
Hasse
B.
contributor
Hirsch
HH.
contributor
Hirschel
B.
contributor
Hösli
I.
contributor
Kahlert
C.
contributor
Kaiser
L.
contributor
Keiser
O.
contributor
Kind
C.
contributor
Klimkait
T.
contributor
Kovari
H.
contributor
Ledergerber
B.
contributor
Martinetti
G.
contributor
Martinez de Tejada
B.
contributor
Metzner
K.
contributor
Müller
N.
contributor
Nadal
D.
contributor
Pantaleo
G.
contributor
Rauch
A.
contributor
Regenass
S.
contributor
Rickenbach
M.
contributor
Rudin
C.
contributor
Schmid
P.
contributor
Schultze
D.
contributor
Schöni-Affolter
F.
contributor
Schüpbach
J.
contributor
Speck
R.
contributor
Taffé
P.
contributor
Tarr
P.
contributor
Telenti
A.
contributor
Trkola
A.
contributor
Vernazza
P.
contributor
Weber
R.
contributor
Prins
YS.
contributor
Kuijpers
TW.
contributor
Scherpbier
HJ.
contributor
Boer
K.
contributor
van der Meer JT.
contributor
Wit
FW.
contributor
Godfried
MH.
contributor
Reiss
P.
contributor
van der Poll
T.
contributor
Nellen
FJ.
contributor
Lange
JM.
contributor
Geerlings
SE.
contributor
van Vugt
M.
contributor
Vrouenraets
SM.
contributor
Pajkrt
D.
contributor
Bos
JC.
contributor
van der Valk
M.
contributor
Schreij
G.
contributor
Lowe
S.
contributor
Lashof
AO.
contributor
Pronk
MJ.
contributor
Bravenboer
B.
contributor
van der Ende ME.
contributor
de Vries-Sluijs TE.
contributor
Schurink
CA.
contributor
van der Feltz
M.
contributor
Nouwen
JL.
contributor
Gelinck
LB.
contributor
Verbon
A.
contributor
Rijnders
BJ.
contributor
van de Ven-de Ruiter ED.
contributor
Slobbe
L.
contributor
Haag
D.
contributor
Kauffmann
RH.
contributor
Schippers
EF.
contributor
Groeneveld
PH.
contributor
Alleman
MA.
contributor
Bouwhuis
JW.
contributor
ten Kate RW.
contributor
Soetekouw
R.
contributor
Kroon
FP.
contributor
van den Broek PJ.
contributor
van Dissel JT.
contributor
Arend
SM.
contributor
van Nieuwkoop
C.
contributor
de Boer MJ.
contributor
Jolink
H.
contributor
den Hollander JG.
contributor
Pogany
K.
contributor
Bronsveld
W.
contributor
Kortmann
W.
contributor
van Twillert
G.
contributor
van Houte DP.
contributor
Polée
MB.
contributor
van Vonderen MG.
contributor
ten Napel CH.
contributor
Kootstra
GJ.
contributor
Brinkman
K.
contributor
Blok
WL.
contributor
Frissen
PH.
contributor
Schouten
WE.
contributor
van den Berk GE.
contributor
Juttmann
JR.
contributor
van Kasteren ME.
contributor
Brouwer
AE.
contributor
Mulder
JW.
contributor
van Gorp EC.
contributor
Smit
PM.
contributor
Weijer
S.
contributor
van Eeden
A.
contributor
Verhagen
DW.
contributor
Sprenger
HG.
contributor
Doedens
R.
contributor
Scholvinck
EH.
contributor
van Assen
S.
contributor
Stek
CJ.
contributor
Hoepelman
IM.
contributor
Mudrikova
T.
contributor
Schneider
MM.
contributor
Jaspers
CA.
contributor
Ellerbroek
PM.
contributor
Peters
EJ.
contributor
Maarschalk-Ellerbroek
LJ.
contributor
Oosterheert
JJ.
contributor
Arends
JE.
contributor
Wassenberg
MW.
contributor
van der Hilst JC.
contributor
Richter
C.
contributor
van der Berg JP.
contributor
Gisolf
EH.
contributor
Margolick
JB.
contributor
Plankey
M.
contributor
Crain
B.
contributor
Dobs
A.
contributor
Farzadegan
H.
contributor
Gallant
J.
contributor
Johnson-Hill
L.
contributor
Sacktor
N.
contributor
Selnes
O.
contributor
Shepard
J.
contributor
Thio
C.
contributor
Phair
JP.
contributor
Wolinsky
SM.
contributor
Badri
S.
contributor
Conover
C.
contributor
O'Gorman
M.
contributor
Ostrow
D.
contributor
Palella
F.
contributor
Ragin
A.
contributor
Detels
R.
contributor
Martínez-Maza
O.
contributor
Aronow
A.
contributor
Bolan
R.
contributor
Breen
E.
contributor
Butch
A.
contributor
Fahey
J.
contributor
Jamieson
B.
contributor
Miller
EN.
contributor
Oishi
J.
contributor
Vinters
H.
contributor
Visscher
BR.
contributor
Wiley
D.
contributor
Witt
M.
contributor
Yang
O.
contributor
Young
S.
contributor
Zhang
ZF.
contributor
Rinaldo
CR.
contributor
Kingsley
LA.
contributor
Becker
JT.
contributor
Cranston
RD.
contributor
Martinson
JJ.
contributor
Mellors
JW.
contributor
Silvestre
AJ.
contributor
Stall
RD.
contributor
Jacobson
LP.
contributor
Muñoz
A.
contributor
Abraham
A.
contributor
Althoff
K.
contributor
Cox
C.
contributor
D'Souza
G.
contributor
Gange
SJ.
contributor
Golub
E.
contributor
Schollenberger
J.
contributor
Seaberg
EC.
contributor
Su
S.
contributor
Huebner
RE.
contributor
Dominguez
G.
contributor
Moroni
M.
contributor
Angarano
G.
contributor
Antinori
A.
contributor
Carosi
G.
contributor
Cauda
R.
contributor
Monforte£££A d'Arminio£££ A.
contributor
Di Perri
G.
contributor
Galli
M.
contributor
Iardino
R.
contributor
Ippolito
G.
contributor
Lazzarin
A.
contributor
Perno
CF.
contributor
Sagnelli
E.
contributor
Viale
PL.
contributor
Von Schlosser
F.
contributor
d'Arminio Monforte
A.
contributor
Ammassari
A.
contributor
Andreoni
M.
contributor
Antinori
A.
contributor
Balotta
C.
contributor
Bonfanti
P.
contributor
Bonora
S.
contributor
Borderi
M.
contributor
Capobianchi
MR.
contributor
Castagna
A.
contributor
Ceccherini-Silberstein
F.
contributor
Cozzi-Lepri
A.
contributor
Monforte£££A d'Arminio£££ A.
contributor
De Luca
A.
contributor
Gargiulo
M.
contributor
Gervasoni
C.
contributor
Girardi
E.
contributor
Lichtner
M.
contributor
Lo Caputo
S.
contributor
Madeddu
G.
contributor
Maggiolo
F.
contributor
Marcotullio
S.
contributor
Monno
L.
contributor
Murri
R.
contributor
Mussini
C.
contributor
Puoti
M.
contributor
Torti
C.
contributor
Cozzi-Lepri
A.
contributor
Fanti
I.
contributor
Formenti
T.
contributor
Galli
L.
contributor
Lorenzini
P.
contributor
Montroni
M.
contributor
Giacometti
A.
contributor
Costantini
A.
contributor
Riva
A.
contributor
Tirelli
U.
contributor
Martellotta
F.
contributor
Angarano
G.
contributor
Monno
L.
contributor
Ladisa
N.
contributor
Maggiolo
F.
contributor
Lazzari
G.
contributor
Viale
PL.
contributor
Borderi
M.
contributor
Verucchi
G.
contributor
Castelli
F.
contributor
Scalzini
A.
contributor
Torti
C.
contributor
Minardi
C.
contributor
Bertelli
D.
contributor
Quirino
T.
contributor
Abeli
C.
contributor
Manconi
PE.
contributor
Piano
P.
contributor
Vecchiet
J.
contributor
Falasca
K.
contributor
Carnevale
G.
contributor
Lorenzotti
S.
contributor
Sighinolfi
L.
contributor
Segala
D.
contributor
Leoncini
F.
contributor
Mazzotta
F.
contributor
Pozzi
M.
contributor
Lo Caputo
S.
contributor
Cassola
G.
contributor
Viscoli
G.
contributor
Viscoli
A.
contributor
Piscopo
R.
contributor
Mazzarello
G.
contributor
Mastroianni
C.
contributor
Belvisi
V.
contributor
Bonfanti
P.
contributor
Caramma
I.
contributor
Chiodera
A.
contributor
Castelli
P.
contributor
Galli
M.
contributor
Lazzarin
A.
contributor
Rizzardini
G.
contributor
Puoti
M.
contributor
Monforte£££A d'Arminio£££ A.
contributor
Ridolfo
AL.
contributor
Foschi
A.
contributor
Castagna
A.
contributor
Salpietro
S.
contributor
Galli
A.
contributor
Bigoloni
A.
contributor
Spagnuolo
V.
contributor
Merli
S.
contributor
Carenzi
L.
contributor
Moioli
MC.
contributor
Cicconi
P.
contributor
Formenti
T.
contributor
Mussini
C.
contributor
Bisio
L.
contributor
Gori
A.
contributor
Lapadula
G.
contributor
Abrescia
N.
contributor
Chirianni
A.
contributor
De Marco
M.
contributor
Gargiulo
M.
contributor
Ferrari
C.
contributor
Borghi
R.
contributor
Baldelli
F.
contributor
Belfiori
B.
contributor
Parruti
G.
contributor
Ursini
T.
contributor
Magnani
G.
contributor
Ursitti
MA.
contributor
Cauda
R.
contributor
Andreoni
M.
contributor
Antinori
A.
contributor
Narciso
P.
contributor
Tozzi
V.
contributor
Vullo
V.
contributor
De Luca
A.
contributor
d'Avino
A.
contributor
Zaccarelli
M.
contributor
Gallo
L.
contributor
Acinapura
R.
contributor
Capozzi
M.
contributor
Libertone
R.
contributor
Trotta
MP.
contributor
Lichtner
M.
contributor
Tebano
G.
contributor
Cattelan
AM.
contributor
Mura
MS.
contributor
Madeddu
G.
contributor
Caramello
P.
contributor
Di Perri
G.
contributor
Orofino
GC.
contributor
Sciandra
M.
contributor
Raise
contributor
Ebo
F.
contributor
Pellizzer
G.
contributor
Manfrin
V.
contributor
Law
M.
contributor
Petoumenos
K.
contributor
McManus
H.
contributor
Wright
S.
contributor
Bendall
C.
contributor
Moore
R.
contributor
Edwards
S.
contributor
article
2013
Clinical Infectious Diseases
1537-6591
1058-4838
journal
57
1
112-121
BACKGROUND: Persons infected with human immunodeficiency virus (HIV) have increased rates of coronary artery disease (CAD). The relative contribution of genetic background, HIV-related factors, antiretroviral medications, and traditional risk factors to CAD has not been fully evaluated in the setting of HIV infection.
METHODS: In the general population, 23 common single-nucleotide polymorphisms (SNPs) were shown to be associated with CAD through genome-wide association analysis. Using the Metabochip, we genotyped 1875 HIV-positive, white individuals enrolled in 24 HIV observational studies, including 571 participants with a first CAD event during the 9-year study period and 1304 controls matched on sex and cohort.
RESULTS: A genetic risk score built from 23 CAD-associated SNPs contributed significantly to CAD (P = 2.9 × 10(-4)). In the final multivariable model, participants with an unfavorable genetic background (top genetic score quartile) had a CAD odds ratio (OR) of 1.47 (95% confidence interval [CI], 1.05-2.04). This effect was similar to hypertension (OR = 1.36; 95% CI, 1.06-1.73), hypercholesterolemia (OR = 1.51; 95% CI, 1.16-1.96), diabetes (OR = 1.66; 95% CI, 1.10-2.49), ≥ 1 year lopinavir exposure (OR = 1.36; 95% CI, 1.06-1.73), and current abacavir treatment (OR = 1.56; 95% CI, 1.17-2.07). The effect of the genetic risk score was additive to the effect of nongenetic CAD risk factors, and did not change after adjustment for family history of CAD.
CONCLUSIONS: In the setting of HIV infection, the effect of an unfavorable genetic background was similar to traditional CAD risk factors and certain adverse antiretroviral exposures. Genetic testing may provide prognostic information complementary to family history of CAD.
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
University of Lausanne
mailto:serval_help@unil.ch
http://www.unil.ch/serval
http://serval.unil.ch/disclaimer
https://serval.unil.ch/notice/serval:BIB_FF946CC0ABE7