serval:BIB_FEDF76FCECC4
A molecular profile of T-cell exhaustion in cancer.
10.4161/onci.18342
22737618
Speiser
D.E.
author
article
editorial
2012
Oncoimmunology
2162-4011
journal
1
3
369-371
The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in "exhausted" T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is reversible and limited to anatomical sites of disease.
eng
60_published
true
peer-reviewed
Publication types: JOURNAL ARTICLE
EDITORIAL
University of Lausanne
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