serval:BIB_FD731E51329C
Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort.
10.1007/s10654-012-9754-y
000318896000008
23546766
Koller
M.T.
author
van Delden
C.
author
Müller
N.J.
author
Baumann
P.
author
Lovis
C.
author
Marti
H.P.
author
Fehr
T.
author
Binet
I.
author
De Geest
S.
author
Bucher
H.C.
author
Meylan
P.
author
Pascual
M.
author
Steiger
J.
author
article
2013
European Journal of Epidemiology
1573-7284
0393-2990
journal
28
4
347-355
In Switzerland, organ procurement is well organized at the national-level but transplant outcomes have not been systematically monitored so far. Therefore, a novel project, the Swiss Transplant Cohort Study (STCS), was established. The STCS is a prospective multicentre study, designed as a dynamic cohort, which enrolls all solid organ recipients at the national level. The features of the STCS are a flexible patient-case system that allows capturing all transplant scenarios and collection of patient-specific and allograft-specific data. Beyond comprehensive clinical data, specific focus is directed at psychosocial and behavioral factors, infectious disease development, and bio-banking. Between May 2008 and end of 2011, the six Swiss transplant centers recruited 1,677 patients involving 1,721 transplantations, and a total of 1,800 organs implanted in 15 different transplantation scenarios. 10 % of all patients underwent re-transplantation and 3% had a second transplantation, either in the past or during follow-up. 34% of all kidney allografts originated from living donation. Until the end of 2011 we observed 4,385 infection episodes in our patient population. The STCS showed operative capabilities to collect high-quality data and to adequately reflect the complexity of the post-transplantation process. The STCS represents a promising novel project for comparative effectiveness research in transplantation medicine.
eng
60_published
true
Publication types: Journal ArticlePublication Status: ppublish
University of Lausanne
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