serval:BIB_FCE6F9BF0468
Systematic review of catheter-based intra-arterial therapies in hepatocellular carcinoma: state of the art and future directions.
10.1259/bjr.20140564
25978585
000363313000006
Duran
R.
author
Chapiro
J.
author
Schernthaner
R.E.
author
Geschwind
J.F.
author
article
review
2015-08
British Journal of Radiology
1748-880X
0007-1285
journal
88
1052
20140564
Intra-arterial therapies (IATs) play a pivotal role in the management of patients with primary and secondary liver malignancies. The unique advantages of these treatments are their ability to selectively deliver a high dose of anticancer treatment while preserving healthy liver tissue. The proven efficacy of these catheter-based locoregional therapies in a highly systemic chemoresistant cancer such as hepatocellular carcinoma (HCC), along with the minimally invasive nature of these treatments, quickly yielded wide acceptance in the medical community and revolutionized the field of Interventional Oncology. In this article, we describe the clinical rationale and background of catheter-based IATs. We provide an overview of clinical achievements of these treatments alone and in combination with sorafenib in patients with HCC.
Angiogenesis Inhibitors/therapeutic use
Antineoplastic Agents/administration & dosage
Carcinoma, Hepatocellular/therapy
Catheter Ablation/methods
Chemoembolization, Therapeutic/methods
Combined Modality Therapy
Diffusion of Innovation
Embolization, Therapeutic/methods
Female
Forecasting
Humans
Infusions, Intra-Arterial
Liver Neoplasms/therapy
Male
Microspheres
Niacinamide/administration & dosage
Niacinamide/analogs & derivatives
Patient Selection
Phenylurea Compounds/administration & dosage
Radiopharmaceuticals/therapeutic use
Yttrium Radioisotopes/therapeutic use
eng
60_published
peer-reviewed
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
Publication Status: ppublish
University of Lausanne
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