serval:BIB_EE8EDC0ACBE8
T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension.
10.1093/nar/gkr245
21558174
Di Tommaso
P.
author
Moretti
S.
author
Xenarios
I.
author
Orobitg
M.
author
Montanyola
A.
author
Chang
J.M.
author
Taly
J.F.
author
Notredame
C.
author
article
2011
Nucleic Acids Research
1362-4962
0305-1048
journal
39
Web Server issue
W13-W17
This article introduces a new interface for T-Coffee, a consistency-based multiple sequence alignment program. This interface provides an easy and intuitive access to the most popular functionality of the package. These include the default T-Coffee mode for protein and nucleic acid sequences, the M-Coffee mode that allows combining the output of any other aligners, and template-based modes of T-Coffee that deliver high accuracy alignments while using structural or homology derived templates. These three available template modes are Expresso for the alignment of protein with a known 3D-Structure, R-Coffee to align RNA sequences with conserved secondary structures and PSI-Coffee to accurately align distantly related sequences using homology extension. The new server benefits from recent improvements of the T-Coffee algorithm and can align up to 150 sequences as long as 10,000 residues and is available from both http://www.tcoffee.org and its main mirror http://tcoffee.crg.cat.
eng
60_published
true
University of Lausanne
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