serval:BIB_E67B8A43EB37
Host genetics and HIV-1: the final phase?
10.1371/journal.ppat.1001033
000283652200002
20976252
Fellay
J.
author
Shianna
K.V.
author
Telenti
A.
author
Goldstein
D.B.
author
article
review
2010
Plos Pathogens
1553-7374[electronic], 1553-7366[linking]
journal
6
10
e1001033
This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.
eng
60_published
true
University of Lausanne
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