serval:BIB_E62BDCCFF932
Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.
10.1152/ajpregu.00241.2010
20686175
000283751200005
Wang
Q.
author
Maillard
M.
author
Schibler
U.
author
Burnier
M.
author
Gachon
F.
author
article
2010
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
1522-1490[electronic], 0363-6119[linking]
journal
299
4
R1013-R1019
The cardiovascular system is under the control of the circadian clock, and disturbed circadian rhythms can induce cardiovascular pathologies. This cyclic regulation is probably brought about by the circadian expression of genes encoding enzymes and regulators involved in cardiovascular functions. We have previously shown that the rhythmic transcription of output genes is, in part, regulated by the clock-controlled PAR bZip transcription factors DBP (albumin D-element Binding Protein), HLF (Hepatic Leukemia Factor), and TEF (Thyrotroph Embryonic Factor). The simultaneous deletion of all three PAR bZip transcription factors leads to increased morbidity and shortened life span. Here, we demonstrate that Dbp/Tef/Hlf triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure. These dysfunctions are exacerbated by an abnormal response to this low blood pressure characterized by low aldosterone levels. The phenotype of PAR bZip knockout mice highlights the importance of circadian regulators in the modulation of cardiovascular functions.
circadian clock, PAR bZip transcription factors, cardiac physiology, blood pressure, kidney function
eng
60_published
peer-reviewed
University of Lausanne
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