serval:BIB_E4D0E1AAA380
Acinar cell carcinoma of the pancreas with thyroid-like follicular features: first description of a new diagnostic challenging subtype.
10.1007/s00428-019-02628-3
000504041800013
31338587
Saglietti
C.
author
Schneider
V.
author
Bongiovanni
M.
author
Missiaglia
E.
author
Bisig
B.
author
Dorta
G.
author
Demartines
N.
author
Sempoux
C.
author
La Rosa
S.
author
article
2019-12
Virchows Archiv
1432-2307
0945-6317
journal
475
6
789-794
Acinar cell carcinomas (ACCs) of the pancreas are a heterogeneous group of neoplasms showing a wide spectrum of morphological features including acinar, solid, glandular, and trabecular architecture. In addition, uncommon cytological aspects have recently been described and include oncocytic, spindle, clear, and pleomorphic cell types. This wide histological spectrum represents a challenge in the diagnostic task for pathologists. Molecular mechanisms involved in the onset and progression of ACCs are not completely known, but, in general, they differ from those observed in ductal adenocarcinomas or neuroendocrine neoplasms of the pancreas and frequently include alterations in the APC/β-catenin pathway. In the present paper, we describe a new variant of ACC showing thyroid-like follicular features and CTNNB1 mutation. This phenotype needs to be included in the spectrum of morphological presentation of ACC.
Carcinoma, Acinar Cell/diagnosis
Carcinoma, Acinar Cell/genetics
Carcinoma, Acinar Cell/pathology
Diagnosis, Differential
Humans
Male
Middle Aged
Mutation/genetics
Pancreatic Neoplasms/diagnosis
Pancreatic Neoplasms/pathology
Thyroid Gland/pathology
beta Catenin/genetics
beta Catenin/metabolism
Acinar cell carcinoma
Differential diagnosis
Morphology
Pancreas
Thyroid-like
eng
60_published
peer-reviewed
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
University of Lausanne
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