serval:BIB_E4C723D9F33C
Large-Scale 3-5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy.
10.1523/ENEURO.0494-18.2019
000461453600047
30783615
Sheybani
L.
author
van Mierlo
P.
author
Birot
G.
author
Michel
C.M.
author
Quairiaux
C.
author
article
2019
eNeuro
2373-2822
2373-2822
journal
6
1
Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. During these epileptic paroxysms, local phase-locking of neuronal firing and a phase-amplitude coupling of the epileptic discharges over a slow oscillation at 3-5 Hz are detected. Furthermore, the buildup of the slow oscillation begins in the bihippocampal network that includes the focus, which synchronizes and drives the activity across the large-scale epileptic network into the frontal cortex. This study provides the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and shows that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
Action Potentials
Animals
Brain Waves/physiology
Disease Models, Animal
Epilepsy, Temporal Lobe/physiopathology
Male
Mice, Inbred C57BL
Neocortex/physiopathology
Neurons/physiology
cross-frequency coupling
epilepsy
epileptic network
fast-ripples
oscillation
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
University of Lausanne
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