serval:BIB_E27A7F7B67AB
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
10.1038/s41467-019-10461-0
000470968400008
31186427
Czamara
D.
author
Eraslan
G.
author
Page
C.M.
author
Lahti
J.
author
Lahti-Pulkkinen
M.
author
Hämäläinen
E.
author
Kajantie
E.
author
Laivuori
H.
author
Villa
P.M.
author
Reynolds
R.M.
author
Nystad
W.
author
Håberg
S.E.
author
London
S.J.
author
O'Donnell
K.J.
author
Garg
E.
author
Meaney
M.J.
author
Entringer
S.
author
Wadhwa
P.D.
author
Buss
C.
author
Jones
M.J.
author
Lin
DTS
author
MacIsaac
J.L.
author
Kobor
M.S.
author
Koen
N.
author
Zar
H.J.
author
Koenen
K.C.
author
Dalvie
S.
author
Stein
D.J.
author
Kondofersky
I.
author
Müller
N.S.
author
Theis
F.J.
author
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
contributor
Räikkönen
K.
author
Binder
E.B.
author
Wray
N.R.
contributor
Ripke
S.
contributor
Mattheisen
M.
contributor
Trzaskowski
M.
contributor
Byrne
E.M.
contributor
Abdellaoui
A.
contributor
Adams
M.J.
contributor
Agerbo
E.
contributor
Air
T.M.
contributor
Andlauer
TFM
contributor
Bacanu
S.A.
contributor
Bækvad-Hansen
M.
contributor
Beekman
ATF
contributor
Bigdeli
T.B.
contributor
Blackwood
DHR
contributor
Bryois
J.
contributor
Buttenschøn
H.N.
contributor
Bybjerg-Grauholm
J.
contributor
Cai
N.
contributor
Castelao
E.
contributor
Christensen
J.H.
contributor
Clarke
T.K.
contributor
Coleman
JRI
contributor
Colodro-Conde
L.
contributor
Couvy-Duchesne
B.
contributor
Craddock
N.
contributor
Crawford
G.E.
contributor
Davies
G.
contributor
Deary
I.J.
contributor
Degenhardt
F.
contributor
Derks
E.M.
contributor
Direk
N.
contributor
Dolan
C.V.
contributor
Dunn
E.C.
contributor
Eley
T.C.
contributor
Escott-Price
V.
contributor
Kiadeh
FFH
contributor
Finucane
H.K.
contributor
Forstner
A.J.
contributor
Frank
J.
contributor
Gaspar
H.A.
contributor
Gill
M.
contributor
Goes
F.S.
contributor
Gordon
S.D.
contributor
Grove
J.
contributor
Hall
L.S.
contributor
Hansen
C.S.
contributor
Hansen
T.F.
contributor
Herms
S.
contributor
Hickie
I.B.
contributor
Hoffmann
P.
contributor
Homuth
G.
contributor
Horn
C.
contributor
Hottenga
J.J.
contributor
Hougaard
D.M.
contributor
Ising
M.
contributor
Jansen
R.
contributor
Jorgenson
E.
contributor
Knowles
J.A.
contributor
Kohane
I.S.
contributor
Kraft
J.
contributor
Kretzschmar
W.W.
contributor
Krogh
J.
contributor
Kutalik
Z.
contributor
Li
Y.
contributor
Lind
P.A.
contributor
MacIntyre
D.J.
contributor
MacKinnon
D.F.
contributor
Maier
R.M.
contributor
Maier
W.
contributor
Marchini
J.
contributor
Mbarek
H.
contributor
McGrath
P.
contributor
McGuffin
P.
contributor
Medland
S.E.
contributor
Mehta
D.
contributor
Middeldorp
C.M.
contributor
Mihailov
E.
contributor
Milaneschi
Y.
contributor
Milani
L.
contributor
Mondimore
F.M.
contributor
Montgomery
G.W.
contributor
Mostafavi
S.
contributor
Mullins
N.
contributor
Nauck
M.
contributor
Ng
B.
contributor
Nivard
M.G.
contributor
Nyholt
D.R.
contributor
O'Reilly
P.F.
contributor
Oskarsson
H.
contributor
Owen
M.J.
contributor
Painter
J.N.
contributor
Pedersen
C.B.
contributor
Pedersen
M.G.
contributor
Peterson
R.E.
contributor
Pettersson
E.
contributor
Peyrot
W.J.
contributor
Pistis
G.
contributor
Posthuma
D.
contributor
Quiroz
J.A.
contributor
Qvist
P.
contributor
Rice
J.P.
contributor
Riley
B.P.
contributor
Rivera
M.
contributor
Mirza
S.S.
contributor
Schoevers
R.
contributor
Schulte
E.C.
contributor
Shen
L.
contributor
Shi
J.
contributor
Shyn
S.I.
contributor
Sigurdsson
E.
contributor
Sinnamon
GCB
contributor
Smit
J.H.
contributor
Smith
D.J.
contributor
Stefansson
H.
contributor
Steinberg
S.
contributor
Streit
F.
contributor
Strohmaier
J.
contributor
Tansey
K.E.
contributor
Teismann
H.
contributor
Teumer
A.
contributor
Thompson
W.
contributor
Thomson
P.A.
contributor
Thorgeirsson
T.E.
contributor
Traylor
M.
contributor
Treutlein
J.
contributor
Trubetskoy
V.
contributor
Uitterlinden
A.G.
contributor
Umbricht
D.
contributor
Van der Auwera
S.
contributor
van Hemert
A.M.
contributor
Viktorin
A.
contributor
Visscher
P.M.
contributor
Wang
Y.
contributor
Webb
B.T.
contributor
Weinsheimer
S.M.
contributor
Wellmann
J.
contributor
Willemsen
G.
contributor
Witt
S.H.
contributor
Wu
Y.
contributor
Xi
H.S.
contributor
Yang
J.
contributor
Zhang
F.
contributor
Arolt
V.
contributor
Baune
B.T.
contributor
Berger
K.
contributor
Boomsma
D.I.
contributor
Cichon
S.
contributor
Dannlowski
U.
contributor
de Geus
EJC
contributor
DePaulo
J.R.
contributor
Domenici
E.
contributor
Domschke
K.
contributor
Esko
T.
contributor
Grabe
H.J.
contributor
Hamilton
S.P.
contributor
Hayward
C.
contributor
Heath
A.C.
contributor
Kendler
K.S.
contributor
Kloiber
S.
contributor
Lewis
G.
contributor
Li
Q.S.
contributor
Lucae
S.
contributor
Madden
PAF
contributor
Magnusson
P.K.
contributor
Martin
N.G.
contributor
McIntosh
A.M.
contributor
Metspalu
A.
contributor
Mors
O.
contributor
Mortensen
P.B.
contributor
Müller-Myhsok
B.
contributor
Nordentoft
M.
contributor
Nöthen
M.M.
contributor
O'Donovan
M.C.
contributor
Paciga
S.A.
contributor
Pedersen
N.L.
contributor
Penninx
BWJH
contributor
Perlis
R.H.
contributor
Porteous
D.J.
contributor
Potash
J.B.
contributor
Preisig
M.
contributor
Rietschel
M.
contributor
Schaefer
C.
contributor
Schulze
T.G.
contributor
Smoller
J.W.
contributor
Stefansson
K.
contributor
Tiemeier
H.
contributor
Uher
R.
contributor
Völzke
H.
contributor
Weissman
M.M.
contributor
Werge
T.
contributor
Lewis
C.M.
contributor
Levinson
D.F.
contributor
Breen
G.
contributor
Børglum
A.D.
contributor
Sullivan
P.F.
contributor
article
2019-06-11
Nature communications
2041-1723
2041-1723
journal
10
1
2548
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
eng
60_published
true
peer-reviewed
Publication types: Journal Article
Publication Status: epublish
University of Lausanne
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