serval:BIB_D28CB2C1FFAA
Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
10.1371/journal.pbio.1000230
000272031800019
19859539
Niquille
Mathieu
author
Garel
Sonia
author
Mann
Fanny
author
Hornung
Jean-Pierre
author
Otsmane
Belkacem
author
Chevalley
Sebastien
author
Parras
Carlos
author
Guillemot
Francois
author
Gaspar
Patricia
author
Yanagawa
Yuchio
author
Lebrand
Cecile
author
article
2009
Plos Biology
1545-7885
journal
7
10
e1000230
The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis is associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities in this structure. Midline glial cells are known to play a role in CC development, but we here show that two transient populations of midline neurons also make major contributions to the formation of this commissure. We report that these two neuronal populations enter the CC midline prior to the arrival of callosal pioneer axons. Using a combination of mutant analysis and in vitro assays, we demonstrate that CC neurons are necessary for normal callosal axon navigation. They exert an attractive influence on callosal axons, in part via Semaphorin 3C and its receptor Neuropilin-1. By revealing a novel and essential role for these neuronal populations in the pathfinding of a major cerebral commissure, our study brings new perspectives to pathophysiological mechanisms altering CC formation.
Lateral Olfactory Tract
Cajal-Retzius Cells
Corpus-Callosum
Tangential Migration
Interneuron Migration
Ganglionic Eminence
Basal Forebrain
Cerebral-Cortex
Nervous-System
Fetal-Brain
eng
60_published
true
peer-reviewed
video sur le site plos et figshare
https://dx.doi.org/10.1371/journal.pbio.1000230
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