serval:BIB_D1DFCD64C973
Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids.
10.1038/nn.3321
23354329
000315474800012
Labouèbe
G.
author
Liu
S.
author
Dias
C.
author
Zou
H.
author
Wong
J.C.
author
Karunakaran
S.
author
Clee
S.M.
author
Phillips
A.G.
author
Boutrel
B.
author
Borgland
S.L.
author
article
2013
Nature Neuroscience
1546-1726
1097-6256
journal
16
3
300-308
The prevalence of obesity has markedly increased over the past few decades. Exploration of how hunger and satiety signals influence the reward system can help us understand non-homeostatic feeding. Insulin may act in the ventral tegmental area (VTA), a critical site for reward-seeking behavior, to suppress feeding. However, the neural mechanisms underlying insulin effects in the VTA remain unknown. We demonstrate that insulin, a circulating catabolic peptide that inhibits feeding, can induce long-term depression (LTD) of mouse excitatory synapses onto VTA dopamine neurons. This effect requires endocannabinoid-mediated presynaptic inhibition of glutamate release. Furthermore, after a sweetened high-fat meal, which elevates endogenous insulin, insulin-induced LTD is occluded. Finally, insulin in the VTA reduces food anticipatory behavior in mice and conditioned place preference for food in rats. Taken together, these results suggest that insulin in the VTA suppresses excitatory synaptic transmission and reduces anticipatory activity and preference for food-related cues.
eng
60_published
peer-reviewed
Publication types: Journal ArticlePublication Status: ppublish
University of Lausanne
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