serval:BIB_CDDC410E5B63
A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease.
10.1007/s10439-014-1117-2
25224078
000350234500012
Andriacchi
T.P.
author
Favre
J.
author
Erhart-Hledik
J.C.
author
Chu
C.R.
author
article
review
2015
Annals of Biomedical Engineering
1573-9686
0090-6964
journal
43
2
376-387
Early detection of osteoarthritis (OA) remains a critical yet unsolved multifaceted problem. To address the multifaceted nature of OA a systems model was developed to consolidate a number of observations on the biological, mechanical and structural components of OA and identify features common to the primary risk factors for OA (aging, obesity and joint trauma) that are present prior to the development of clinical OA. This analysis supports a unified view of the pathogenesis of OA such that the risk for developing OA emerges when one of the components of the disease (e.g., mechanical) becomes abnormal, and it is the interaction with the other components (e.g., biological and/or structural) that influences the ultimate convergence to cartilage breakdown and progression to clinical OA. The model, applied in a stimulus-response format, demonstrated that a mechanical stimulus at baseline can enhance the sensitivity of a biomarker to predict cartilage thinning in a 5 year follow-up in patients with knee OA. The systems approach provides new insight into the pathogenesis of the disease and offers the basis for developing multidisciplinary studies to address early detection and treatment at a stage in the disease where disease modification has the greatest potential for a successful outcome.
eng
60_published
peer-reviewed
Publication types: Journal Article Publication Status: ppublish
type validé Bibliomics
University of Lausanne
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