serval:BIB_C465F0F1D8F8
MicroRNA-155 Is Required for Effector CD8(+) T Cell Responses to Virus Infection and Cancer.
10.1016/j.immuni.2012.12.006
000330942100016
23601686
Dudda
J.C.
author
Salaun
B.
author
Ji
Y.
author
Palmer
D.C.
author
Monnot
G.C.
author
Merck
E.
author
Boudousquie
C.
author
Utzschneider
D.T.
author
Escobar
T.M.
author
Perret
R.
author
Muljo
S.A.
author
Hebeisen
M.
author
Rufer
N.
author
Zehn
D.
author
Donda
A.
author
Restifo
N.P.
author
Held
W.
author
Gattinoni
L.
author
Romero
P.
author
article
2013
Immunity
1097-4180
1074-7613
journal
38
4
742-753
MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting CD8(+) T cell immunity remains unknown. Here we report that miRNA-155 is required for CD8(+) T cell responses to both virus and cancer. In the absence of miRNA-155, accumulation of effector CD8(+) T cells was severely reduced during acute and chronic viral infections and control of virus replication was impaired. Similarly, Mir155(-/-) CD8(+) T cells were ineffective at controlling tumor growth, whereas miRNA-155 overexpression enhanced the antitumor response. miRNA-155 deficiency resulted in accumulation of suppressor of cytokine signaling-1 (SOCS-1) causing defective cytokine signaling through STAT5. Consistently, enforced expression of SOCS-1 in CD8(+) T cells phenocopied the miRNA-155 deficiency, whereas SOCS-1 silencing augmented tumor destruction. These findings identify miRNA-155 and its target SOCS-1 as key regulators of effector CD8(+) T cells that can be modulated to potentiate immunotherapies for infectious diseases and cancer.
eng
60_published
true
peer-reviewed
Publication types: Journal ArticlePublication Status: ppublish
University of Lausanne
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