serval:BIB_BEBF1B4B6D94
Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans.
10.1016/j.ajpath.2010.12.039
000298306700025
21435450
Link
A.
author
Hardie
D.L.
author
Favre
S.
author
Britschgi
M.R.
author
Adams
D.H.
author
Sixt
M.
author
Cyster
J.G.
author
Buckley
C.D.
author
Luther
S.A.
author
article
2011
American Journal of Pathology
1525-2191
0002-9440
journal
178
4
1662-1675
Ectopic or tertiary lymphoid tissues (TLTs) are often induced at sites of chronic inflammation. They typically contain various hematopoietic cell types, high endothelial venules, and follicular dendritic cells; and are organized in lymph node-like structures. Although fibroblastic stromal cells may play a role in TLT induction and persistence, they have remained poorly defined. Herein, we report that TLTs arising during inflammation in mice and humans in a variety of tissues (eg, pancreas, kidney, liver, and salivary gland) contain stromal cell networks consisting of podoplanin(+) T-zone fibroblastic reticular cells (TRCs), distinct from follicular dendritic cells. Similar to lymph nodes, TRCs were present throughout T-cell-rich areas and had dendritic cells associated with them. They expressed lymphotoxin (LT) β receptor (LTβR), produced CCL21, and formed a functional conduit system. In rat insulin promoter-CXCL13-transgenic pancreas, the maintenance of TRC networks and conduits was partially dependent on LTβR and on lymphoid tissue inducer cells expressing LTβR ligands. In conclusion, TRCs and conduits are hallmarks of secondary lymphoid organs and of well-developed TLTs, in both mice and humans, and are likely to act as important scaffold and organizer cells of the T-cell-rich zone.
Animals
Chemokine CXCL13/genetics
Dendritic Cells/metabolism
Fibroblasts/metabolism
Humans
Inflammation
Insulin/genetics
Ligands
Lymph Nodes/metabolism
Lymphoid Tissue/metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
Pancrelipase/metabolism
Promoter Regions, Genetic
Rats
Stromal Cells/cytology
eng
60_published
true
University of Lausanne
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