serval:BIB_BCBAFC9AB2BB
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
10.1038/s41588-018-0090-3
000431394900010
29700475
Wray
N.R.
author
Ripke
S.
author
Mattheisen
M.
author
Trzaskowski
M.
author
Byrne
E.M.
author
Abdellaoui
A.
author
Adams
M.J.
author
Agerbo
E.
author
Air
T.M.
author
Andlauer
TMF
author
Bacanu
S.A.
author
Bækvad-Hansen
M.
author
Beekman
AFT
author
Bigdeli
T.B.
author
Binder
E.B.
author
Blackwood
DRH
author
Bryois
J.
author
Buttenschøn
H.N.
author
Bybjerg-Grauholm
J.
author
Cai
N.
author
Castelao
E.
author
Christensen
J.H.
author
Clarke
T.K.
author
Coleman
JIR
author
Colodro-Conde
L.
author
Couvy-Duchesne
B.
author
Craddock
N.
author
Crawford
G.E.
author
Crowley
C.A.
author
Dashti
H.S.
author
Davies
G.
author
Deary
I.J.
author
Degenhardt
F.
author
Derks
E.M.
author
Direk
N.
author
Dolan
C.V.
author
Dunn
E.C.
author
Eley
T.C.
author
Eriksson
N.
author
Escott-Price
V.
author
Kiadeh
FHF
author
Finucane
H.K.
author
Forstner
A.J.
author
Frank
J.
author
Gaspar
H.A.
author
Gill
M.
author
Giusti-Rodríguez
P.
author
Goes
F.S.
author
Gordon
S.D.
author
Grove
J.
author
Hall
L.S.
author
Hannon
E.
author
Hansen
C.S.
author
Hansen
T.F.
author
Herms
S.
author
Hickie
I.B.
author
Hoffmann
P.
author
Homuth
G.
author
Horn
C.
author
Hottenga
J.J.
author
Hougaard
D.M.
author
Hu
M.
author
Hyde
C.L.
author
Ising
M.
author
Jansen
R.
author
Jin
F.
author
Jorgenson
E.
author
Knowles
J.A.
author
Kohane
I.S.
author
Kraft
J.
author
Kretzschmar
W.W.
author
Krogh
J.
author
Kutalik
Z.
author
Lane
J.M.
author
Li
Y.
author
Li
Y.
author
Lind
P.A.
author
Liu
X.
author
Lu
L.
author
MacIntyre
D.J.
author
MacKinnon
D.F.
author
Maier
R.M.
author
Maier
W.
author
Marchini
J.
author
Mbarek
H.
author
McGrath
P.
author
McGuffin
P.
author
Medland
S.E.
author
Mehta
D.
author
Middeldorp
C.M.
author
Mihailov
E.
author
Milaneschi
Y.
author
Milani
L.
author
Mill
J.
author
Mondimore
F.M.
author
Montgomery
G.W.
author
Mostafavi
S.
author
Mullins
N.
author
Nauck
M.
author
Ng
B.
author
Nivard
M.G.
author
Nyholt
D.R.
author
O'Reilly
P.F.
author
Oskarsson
H.
author
Owen
M.J.
author
Painter
J.N.
author
Pedersen
C.B.
author
Pedersen
M.G.
author
Peterson
R.E.
author
Pettersson
E.
author
Peyrot
W.J.
author
Pistis
G.
author
Posthuma
D.
author
Purcell
S.M.
author
Quiroz
J.A.
author
Qvist
P.
author
Rice
J.P.
author
Riley
B.P.
author
Rivera
M.
author
Saeed Mirza
S.
author
Saxena
R.
author
Schoevers
R.
author
Schulte
E.C.
author
Shen
L.
author
Shi
J.
author
Shyn
S.I.
author
Sigurdsson
E.
author
Sinnamon
GBC
author
Smit
J.H.
author
Smith
D.J.
author
Stefansson
H.
author
Steinberg
S.
author
Stockmeier
C.A.
author
Streit
F.
author
Strohmaier
J.
author
Tansey
K.E.
author
Teismann
H.
author
Teumer
A.
author
Thompson
W.
author
Thomson
P.A.
author
Thorgeirsson
T.E.
author
Tian
C.
author
Traylor
M.
author
Treutlein
J.
author
Trubetskoy
V.
author
Uitterlinden
A.G.
author
Umbricht
D.
author
Van der Auwera
S.
author
van Hemert
A.M.
author
Viktorin
A.
author
Visscher
P.M.
author
Wang
Y.
author
Webb
B.T.
author
Weinsheimer
S.M.
author
Wellmann
J.
author
Willemsen
G.
author
Witt
S.H.
author
Wu
Y.
author
Xi
H.S.
author
Yang
J.
author
Zhang
F.
author
eQTLGen
contributor
23andMe
contributor
Arolt
V.
author
Baune
B.T.
author
Berger
K.
author
Boomsma
D.I.
author
Cichon
S.
author
Dannlowski
U.
author
de Geus
ECJ
author
DePaulo
J.R.
author
Domenici
E.
author
Domschke
K.
author
Esko
T.
author
Grabe
H.J.
author
Hamilton
S.P.
author
Hayward
C.
author
Heath
A.C.
author
Hinds
D.A.
author
Kendler
K.S.
author
Kloiber
S.
author
Lewis
G.
author
Li
Q.S.
author
Lucae
S.
author
Madden
PFA
author
Magnusson
P.K.
author
Martin
N.G.
author
McIntosh
A.M.
author
Metspalu
A.
author
Mors
O.
author
Mortensen
P.B.
author
Müller-Myhsok
B.
author
Nordentoft
M.
author
Nöthen
M.M.
author
O'Donovan
M.C.
author
Paciga
S.A.
author
Pedersen
N.L.
author
Penninx
BWJH
author
Perlis
R.H.
author
Porteous
D.J.
author
Potash
J.B.
author
Preisig
M.
author
Rietschel
M.
author
Schaefer
C.
author
Schulze
T.G.
author
Smoller
J.W.
author
Stefansson
K.
author
Tiemeier
H.
author
Uher
R.
author
Völzke
H.
author
Weissman
M.M.
author
Werge
T.
author
Winslow
A.R.
author
Lewis
C.M.
author
Levinson
D.F.
author
Breen
G.
author
Børglum
A.D.
author
Sullivan
P.F.
author
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
contributor
article
2018-05
Nature genetics
1546-1718
1061-4036
journal
50
5
668-681
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
Case-Control Studies
Depressive Disorder, Major/genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study/methods
Humans
Male
Multifactorial Inheritance
Phenotype
Polymorphism, Single Nucleotide
Risk Factors
Schizophrenia/genetics
eng
60_published
peer-reviewed
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
University of Lausanne
mailto:serval_help@unil.ch
http://www.unil.ch/serval
http://serval.unil.ch/disclaimer
https://serval.unil.ch/notice/serval:BIB_BCBAFC9AB2BB