serval:BIB_B81E53EE97B7
Role of the renal circadian timing system in maintaining water and electrolytes homeostasis.
10.1016/j.mce.2011.06.037
000300746600008
21763748
Firsov
D.
author
Tokonami
N.
author
Bonny
O.
author
article
review
2012
Molecular and Cellular Endocrinology
1872-8057
0303-7207
journal
349
1
51-55
Many basic physiological functions exhibit circadian rhythmicity. These functional rhythms are driven, in part, by the circadian clock, an ubiquitous molecular mechanism allowing cells and tissues to anticipate regular environmental events and to prepare for them. This mechanism has been shown to play a particularly important role in maintaining stability (homeostasis) of internal conditions. Because the homeostatic equilibrium is continuously challenged by environmental changes, the role of the circadian clock is thought to consist in the anticipative adjustment of homeostatic pathways in relation with the 24h environmental cycle. The kidney is the principal organ responsible for the regulation of the composition and volume of extracellular fluids (ECF). Several major parameters of kidney function, including renal plasma flow (RPF), glomerular filtration rate (GFR) and tubular reabsorption and secretion have been shown to exhibit strong circadian oscillations. Recent evidence suggest that the circadian clock can be involved in generation of these rhythms through external circadian time cues (e.g. humoral factors, activity and body temperature rhythms) or, trough the intrinsic renal circadian clock. Here, we discuss the role of renal circadian mechanisms in maintaining homeostasis of water and three major ions, namely, Na(+), K(+) and Cl(-).
Animals
Chlorides/metabolism
Circadian Clocks
Circadian Rhythm
Homeostasis
Hormones/metabolism
Humans
Kidney/metabolism
Kidney/physiology
Potassium/metabolism
Sodium/metabolism
Water/metabolism
Water-Electrolyte Balance
eng
60_published
true
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
University of Lausanne
mailto:serval_help@unil.ch
http://www.unil.ch/serval
http://serval.unil.ch/disclaimer
https://serval.unil.ch/notice/serval:BIB_B81E53EE97B7