serval:BIB_B327FB1F0DEC
A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects.
10.1017/S000711450789547X
000257952000022
18205992
Abdel-Sayed
A.
author
Binnert
C.
author
LĂȘ
K.A.
author
Bortolotti
M.
author
Schneiter
P.
author
Tappy
L.
author
article
2008
British Journal of Nutrition
0007-1145
journal
100
2
393-399
The effects of a 7 d high-fructose diet (HFrD) or control diet on lipid metabolism were studied in a group of six healthy lean males. Plasma NEFA and beta-hydroxybutyrate concentrations, net lipid oxidation (indirect calorimetry) and exogenous lipid oxidation (13CO2 production) were monitored in basal conditions, after lipid loading (olive oil labelled with [13C]triolein) and during a standardised mental stress. Lactate clearance and the metabolic effects of an exogenous lactate infusion were also monitored. The HFrD lowered plasma concentrations of NEFA and beta-hydroxybutyrate as well as lipid oxidation in both basal and after lipid-loading conditions. In addition, the HFrD blunted the increase in plasma NEFA and exogenous lipid oxidation during mental stress. The HFrD also increased basal lactate concentrations by 31.8 %, and lactate production by 53.8 %, while lactate clearance remained unchanged. Lactate infusion lowered plasma NEFA with the control diet, and net lipid oxidation with both the HFrD and control diet. These results indicate that a 7 d HFrD markedly inhibits lipolysis and lipid oxidation. The HFrD also increases lactate production, and the ensuing increased lactate utilisation may contribute to suppress lipid oxidation.
3-Hydroxybutyric Acid
Adult
Basal Metabolism
Blood Glucose
Diet
Energy Metabolism
Fatty Acids, Nonesterified
Fructose
Humans
Lactic Acid
Lipid Metabolism
Male
Nutritional Physiological Phenomena
Stress, Psychological
eng
60_published
true
peer-reviewed
University of Lausanne
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