serval:BIB_B12AF5A12E11
Multisensory interactions within human primary cortices revealed by BOLD dynamics.
10.1093/cercor/bhl077
000247349000017
16968869
Martuzzi
R.
author
Murray
M.M.
author
Michel
C.M.
author
Thiran
J.P.
author
Maeder
P.P.
author
Clarke
S.
author
Meuli
R.A.
author
article
2007
Cerebral Cortex
1047-3211
journal
17
7
1672-1679
Whether signals from different sensory modalities converge and interact within primary cortices in humans is unresolved, despite emerging evidence in animals. This is partially because of debates concerning the appropriate analyses of functional magnetic resonance imaging (fMRI) data in response to multisensory phenomena. Using event-related fMRI, we observed that simple auditory stimuli (noise bursts) activated primary visual cortices and that simple visual stimuli (checkerboards) activated primary auditory cortices, indicative of multisensory convergence. Moreover, analyses of blood oxygen level-dependent response dynamics revealed facilitation of hemodynamic response peak latencies and slopes for multisensory auditory-visual stimuli versus either unisensory condition, indicative of multisensory interactions within primary sensory cortices. Neural processing at the lowest cortical levels can be modulated by interactions between the senses. Temporal information in fMRI data can reveal these modulations and overcome analytic and interpretational challenges of more traditional procedures. In addition to providing an essential translational link with animal models, these results suggest that longstanding notions of cortical organization need to be revised to include multisensory interactions as an inherent component of functional brain organization.
Acoustic Stimulation
Adult
Auditory Cortex
Auditory Perception
Blood Flow Velocity
Brain Mapping
Evoked Potentials, Auditory
Evoked Potentials, Visual
Female
Humans
Magnetic Resonance Imaging
Male
Oxygen
Photic Stimulation
Visual Cortex
Visual Perception
eng
60_published
true
peer-reviewed
University of Lausanne
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