serval:BIB_AF212E1BAC29
Nosocomial outbreak of multiple bloodborne viral infections
10.1086/322036
000169961600018
11443566
Yerly
S.
author
Quadri
R.
author
Negro
F.
author
Barbe
K. P.
author
Cheseaux
J. J.
author
Burgisser
P.
author
Siegrist
C. A.
author
Perrin
L.
author
article
2001-08
Journal of Infectious Diseases
0022-1899
journal
184
3
369-72
In resource-limited countries, nosocomial transmission of bloodborne pathogens is a major public health concern. After a major outbreak of human immunodeficiency virus (HIV) infection in approximately 400 children in 1998 in Libya, we tested HIV, hepatitis C virus (HCV), and hepatitis B virus (HBV) markers in 148 children and collected epidemiological data in a subgroup of 37 children and 46 parents. HIV infection was detected in all children but one, with HCV or HBV coinfection in 47% and 33%, respectively. Vertical transmission was ruled out by analysis of parents' serology. The children visited the same hospital 1-6 times; at each visit, invasive procedures with potential blood transmission of virus were performed. HIV and HCV genotypic analyses identified a HIV monophyletic group, whereas 4 clusters of HCV sequences were identified. To our knowledge, this is the largest documented outbreak of nosocomial HIV transmission.
Adult
*Blood-Borne Pathogens
Child
Cross Infection/*epidemiology
*Disease Outbreaks
Genotype
HIV Infections/blood/diagnosis/*epidemiology
HIV-1/classification/genetics/*isolation & purification
Hepacivirus/genetics/isolation & purification
Hepatitis B/blood/diagnosis/*epidemiology
Hepatitis B Antibodies/blood
Hepatitis C/blood/diagnosis/*epidemiology
Hepatitis C Antibodies/blood
Humans
Libya/epidemiology/ethnology
Parents
Phylogeny
RNA, Viral/blood/isolation & purification
Switzerland
Viremia/diagnosis/epidemiology
60_published
true
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
University of Lausanne
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