serval:BIB_9AC54B4069AC
Exploring the clinical relevance of a dichotomy between affective and non-affective psychosis: Results from a first-episode psychosis cohort study.
10.1111/eip.13143
000631206300001
33751798
Ramain
J.
author
Conus
P.
author
Golay
P.
author
article
2022-02
Early intervention in psychiatry
1751-7893
1751-7885
journal
16
2
168-177
Defining diagnosis is complex in early psychosis, which may delay the introduction of an appropriate treatment. The dichotomy of affective and non-affective psychosis is used in clinical setting but remains questioned on a scientific basis. In this study, we explore the clinical relevance of this dichotomy on the basis of clinical variables in a sample of first-episode psychosis patients.
We conducted a prospective study in a sample of 330 first-episode psychosis treated at an early intervention program. Affective and non-affective psychosis patients were compared on premorbid history, baseline data, outcomes and course of symptoms over the 3 years of treatment.
Affective psychosis patients (22.42%) were more likely to be female, and had a shorter duration of untreated psychosis. The longitudinal analyses revealed that positive symptoms remained higher over the entire follow-up in the non-affective sub-group. A higher degree of variability of manic symptoms and a significantly better insight after 6 months were observed in the affective sub-group. No difference was observed regarding depressive and negative symptoms. At discharge, only the environmental quality of life and insight recovery were better in affective psychosis.
Our study suggests that despite marginal differences at baseline presentation, these sub-groups differ regarding outcome, which may require differentiation of treatment and supports the utility of this dichotomy.
Cohort Studies
Female
Humans
Male
Prospective Studies
Psychotic Disorders/complications
Psychotic Disorders/diagnosis
Psychotic Disorders/psychology
Quality of Life
Time Factors
early medical intervention
mood disorders
patient outcome assessment
psychotic disorders
symptom assessment
eng
60_published
SNF//51AU40_185897
SNF//320030_122419
true
peer-reviewed
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
University of Lausanne
mailto:serval_help@unil.ch
http://www.unil.ch/serval
http://serval.unil.ch/disclaimer
https://serval.unil.ch/notice/serval:BIB_9AC54B4069AC