serval:BIB_97361904F0E3
Sweet taste loss in myasthenia gravis: more than a coincidence?
10.1186/1750-1172-9-50
000335258200002
24725416
Chabwine
J.N.
author
Tschirren
M.V.
author
Zekeridou
A.
author
Landis
B.N.
author
Kuntzer
T.
author
article
letter
2014
Orphanet Journal of Rare Diseases
1750-1172
1750-1172
journal
9
1
50-53
Sweet dysgeusia, a rare taste disorder, may be encountered in severe anti-acetylcholine receptor antibody (AChRAb)-myasthenia gravis (MG). A 42 year-old man reported progressive loss of sweet taste evolving for almost 10 weeks, revealing an AChRAb-positive MG with thymoma. Improvement of sweet perception paralleled reduction of the MG composite score during the 15 months follow up period, with immunosuppressive and surgical treatments. We suggest that sweet dysgeusia is a non-motor manifestation of MG that may result from a thymoma-dependent autoimmune mechanism targeting gustducin-positive G-protein-coupled taste receptor cells, in line with recent data from MRL/MpJ-Fas lpr/ (MRL/lpr) transgenic mice with autoimmune disease.
eng
60_published
true
peer-reviewed
Publication types: Letter Publication Status: epublish
University of Lausanne
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