serval:BIB_86D58F4F4348
Common genetic variation and the control of HIV-1 in humans.
10.1371/journal.pgen.1000791
000273469700041
20041166
Fellay
J.
author
Ge
D.
author
Shianna
K.V.
author
Colombo
S.
author
Ledergerber
B.
author
Cirulli
E.T.
author
Urban
T.J.
author
Zhang
K.
author
Gumbs
C.E.
author
Smith
J.P.
author
Castagna
A.
author
Cozzi-Lepri
A.
author
De Luca
A.
author
Easterbrook
P.
author
Günthard
H.F.
author
Mallal
S.
author
Mussini
C.
author
Dalmau
J.
author
Martinez-Picado
J.
author
Miro
J.M.
author
Obel
N.
author
Wolinsky
S.M.
author
Martinson
J.J.
author
Detels
R.
author
Margolick
J.B.
author
Jacobson
L.P.
author
Descombes
P.
author
Antonarakis
S.E.
author
Beckmann
J.S.
author
O'Brien
S.J.
author
Letvin
N.L.
author
McMichael
A.J.
author
Haynes
B.F.
author
Carrington
M.
author
Feng
S.
author
Telenti
A.
author
Goldstein
D.B.
author
NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
contributor
article
2009-12
PLoS genetics
1553-7404
1553-7390
journal
5
12
e1000791
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Adult
Alleles
Disease Progression
Female
Genetic Variation
Genotype
HIV Infections/virology
HIV-1/physiology
Humans
Kaplan-Meier Estimate
Major Histocompatibility Complex/genetics
Male
Phenotype
Polymorphism, Single Nucleotide/genetics
Viral Load
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
Publication Status: ppublish
University of Lausanne
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