serval:BIB_7A5968ADA94D
Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.
10.3389/fimmu.2018.01927
000443144000001
30214442
Juilland
M.
author
Thome
M.
author
article
review
2018
Frontiers in immunology
1664-3224
1664-3224
journal
9
1927
The scaffold proteins CARMA1-3 (encoded by the genes CARD11, -14 and -10) and CARD9 play major roles in signaling downstream of receptors with immunoreceptor tyrosine activation motifs (ITAMs), G-protein coupled receptors (GPCR) and receptor tyrosine kinases (RTK). These receptors trigger the formation of oligomeric CARMA/CARD-BCL10-MALT1 (CBM) complexes via kinases of the PKC family. The CBM in turn regulates gene expression by the activation of NF-κB and AP-1 transcription factors and controls transcript stability. The paracaspase MALT1 is the only CBM component having an enzymatic (proteolytic) activity and has therefore recently gained attention as a potential drug target. Here we review recent advances in the understanding of the molecular function of the protease MALT1 and summarize how MALT1 scaffold and protease function contribute to the transmission of CBM signals. Finally, we will highlight how dysregulation of MALT1 function can cause pathologies such as immunodeficiency, autoimmunity, psoriasis, and cancer.
Autoimmune Diseases/immunology
Autoimmune Diseases/therapy
CARD Signaling Adaptor Proteins/immunology
Common Variable Immunodeficiency/immunology
Common Variable Immunodeficiency/pathology
Common Variable Immunodeficiency/therapy
Humans
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/immunology
NF-kappa B/immunology
Neoplasm Proteins/immunology
Neoplasms/immunology
Neoplasms/pathology
Neoplasms/therapy
Signal Transduction/immunology
Transcription Factor AP-1/immunology
BCR
EGFR
GPCR
RNA stability
TCR
Treg
paracaspase
ubiquitin
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
University of Lausanne
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