serval:BIB_7951F9D906D0
Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy.
10.1093/ofid/ofz464
31988971
Barceló
C.
author
Guidi
M.
author
Thorball
C.W.
author
Hammer
C.
author
Chaouch
A.
author
Scherrer
A.U.
author
Hasse
B.
author
Cavassini
M.
author
Furrer
H.
author
Calmy
A.
author
Haubitz
S.
author
Bernasconi
E.
author
Buclin
T.
author
Fellay
J.
author
Tarr
P.E.
author
Csajka
C.
author
Swiss HIV Cohort Study
contributor
Anagnostopoulos
A.
contributor
Battegay
M.
contributor
Bernasconi
E.
contributor
Böni
J.
contributor
Braun
D.L.
contributor
Bucher
H.C.
contributor
Calmy
A.
contributor
Cavassini
M.
contributor
Ciuffi
A.
contributor
Dollenmaier
G.
contributor
Egger
M.
contributor
Elzi
L.
contributor
Fehr
J.
contributor
Fellay
J.
contributor
Furrer
H.
contributor
Fux
C.A.
contributor
Günthard
H.F.
contributor
Haerry
D.
contributor
Hasse
B.
contributor
Hirsch
H.H.
contributor
Hoffmann
M.
contributor
Hösli
I.
contributor
Huber
M.
contributor
Kahlert
C.R.
contributor
Kaiser
L.
contributor
Keiser
O.
contributor
Klimkait
T.
contributor
Kouyos
R.D.
contributor
Kovari
H.
contributor
Ledergerber
B.
contributor
Martinetti
G.
contributor
Martinez de Tejada
B.
contributor
Marzolini
C.
contributor
Metzner
K.J.
contributor
Müller
N.
contributor
Nicca
D.
contributor
Paioni
P.
contributor
Pantaleo
G.
contributor
Perreau
M.
contributor
Rauch
A.
contributor
Rudin
C.
contributor
Scherrer
A.U.
contributor
Schmid
P.
contributor
Speck
R.
contributor
Stöckle
M.
contributor
Tarr
P.
contributor
Trkola
A.
contributor
Vernazza
P.
contributor
Wandeler
G.
contributor
Weber
R.
contributor
Yerly
S.
contributor
article
2020-01
Open forum infectious diseases
2328-8957
2328-8957
journal
7
1
ofz464
There is limited data on abdominal obesity and the influence of genetics on weight change after antiretroviral therapy (ART) initiation. We assessed body mass index (BMI) and waist hip ration (WHR) change over time in the Swiss HIV Cohort study (SHCS).
Mixed-effects models characterizing BMI and WHR change over time in 1090 SHCS participants initiating ART between 2005 and 2015 were developed and used to quantify the influence of demographics, clinical factors, and genetic background.
Individuals with CD4 nadir <100 cells/µL gained 6.4 times more BMI than individuals with ≥200, and 2.8 times more WHR than individuals with ≥100 (P < .001) during the first 1.5 and 2.5 years after ART initiation, respectively. The risk of being overweight or obese after 1.5 years increased with CD4 nadir <100 cells/µL compared to 100-199 (odds ratio [OR], 2.07; 95% confidence interval [CI], 1.63-2.74) and ≥200 (OR, 1.69; 95% CI, 1.26-2.32), persisting after 10 years of ART. The risk of abdominal obesity after 2.5 years increased with CD4 nadir <100 compared to ≥100 (OR, 1.35; 95% CI, 1.17-1.54 [in men]; OR, 1.36; 95% CI, 1.18-1.57 [in women]), persisting after 10 years of ART. No significant differences were found across antiretroviral drug classes or genetic scores.
The risk of general and abdominal obesity increased with CD4 nadir <100 cells/µL. Based on our results, including the genetic background would not improve obesity predictions in HIV-infected individuals.
abdominal obesity
antiretroviral therapy
body mass index
genetics
nadir CD4 cell count
obesity
waist-hip ratio
eng
60_published
true
peer-reviewed
Publication types: Journal Article
Publication Status: epublish
University of Lausanne
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