serval:BIB_713DAFDC1C95
Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.
10.1007/s00018-020-03485-z
000519496900001
32157317
Caputo
T.
author
Tran
VDT
author
Bararpour
N.
author
Winkler
C.
author
Aguileta
G.
author
Trang
KB
author
Giordano Attianese
GMP
author
Wilson
A.
author
Thomas
A.
author
Pagni
M.
author
Guex
N.
author
Desvergne
B.
author
Gilardi
F.
author
article
2021-01
Cellular and molecular life sciences
1420-9071
1420-682X
journal
78
1
227-247
Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poorly understood. By combining transcriptomics, ChIP-seq and modeling approaches, we studied the global early and late responses to a high-fat diet (HFD) in visceral (vWAT) and subcutaneous (scWAT) AT, the first being more prone to obesity-induced inflammation. HFD rapidly triggers proliferation of adipocyte precursors within vWAT. However, concomitant antiadipogenic signals limit vWAT hyperplastic expansion by interfering with the differentiation of proliferating adipocyte precursors. Conversely, in scWAT, residing beige adipocytes lose their oxidizing properties and allow storage of excessive fatty acids. This phase is followed by tissue hyperplastic growth and increased angiogenic signals, which further enable scWAT expansion without generating inflammation. Our data indicate that scWAT and vWAT differential ability to modulate adipocyte number and differentiation in response to obesogenic stimuli has a crucial impact on the different susceptibility to obesity-related inflammation of these adipose tissue depots.
Adipogenesis
Adipose Tissue, White/cytology
Adipose Tissue, White/metabolism
Adipose Tissue, White/pathology
Animals
Cell Differentiation
Diet, High-Fat
Fatty Acid-Binding Proteins/genetics
Fatty Acid-Binding Proteins/metabolism
Gene Expression Regulation
Inflammation/etiology
Inflammation/metabolism
Inflammation/pathology
Interleukin-1beta/genetics
Interleukin-1beta/metabolism
Intra-Abdominal Fat/cytology
Intra-Abdominal Fat/metabolism
Intra-Abdominal Fat/pathology
Lipid Metabolism
Male
Mice
Mice, Inbred C57BL
Obesity/complications
Obesity/pathology
Signal Transduction/genetics
Stem Cells/cytology
Stem Cells/metabolism
Subcutaneous Fat/cytology
Subcutaneous Fat/metabolism
Subcutaneous Fat/pathology
Tumor Necrosis Factor-alpha/genetics
Tumor Necrosis Factor-alpha/metabolism
Wnt Proteins/metabolism
Adipocyte precursors
Adipose tissue
Angiogenesis
Epigenetics
Genome-scale metabolic network
Metaflammation
System biology
Transcriptomics
eng
60_published
SNF//310030_156771
true
peer-reviewed
Publication types: Journal Article
Publication Status: ppublish
University of Lausanne
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