serval:BIB_70C5A8B1F2B8
Role of Chlamydia trachomatis in miscarriage.
10.3201/eid1709.100865
000294656100007
21888787
Baud
D.
author
Goy
G.
author
Jaton
K.
author
Osterheld
M.C.
author
Blumer
S.
author
Borel
N.
author
Vial
Y.
author
Hohlfeld
P.
author
Pospischil
A.
author
Greub
G.
author
article
2011
Emerging Infectious Diseases
1080-6059
1080-6040
journal
17
9
1630-1635
To determine the role of Chlamydia trachomatis in miscarriage, we prospectively collected serum, cervicovaginal swab specimens, and placental samples from 386 women with and without miscarriage. Prevalence of immunoglobulin G against C. trachomatis was higher in the miscarriage group than in the control group (15.2% vs. 7.3%; p = 0.018). Association between C. trachomatis-positive serologic results and miscarriage remained significant after adjustment for age, origin, education, and number of sex partners (odds ratio 2.3, 95% confidence interval 1.1-4.9). C. trachomatis DNA was more frequently amplified from products of conception or placenta from women who had a miscarriage (4%) than from controls (0.7%; p = 0.026). Immunohistochemical analysis confirmed C. trachomatis in placenta from 5 of 7 patients with positive PCR results, whereas results of immunohistochemical analysis were negative in placenta samples from all 8 negative controls tested. Associations between miscarriage and serologic/molecular evidence of C. trachomatis infection support its role in miscarriage.
Abortion, Spontaneous/etiology
Abortion, Spontaneous/immunology
Adult
Chlamydia Infections/complications
Chlamydia trachomatis/genetics
Chlamydia trachomatis/immunology
DNA, Bacterial/analysis
Female
Humans
Multivariate Analysis
Placenta/microbiology
Pregnancy
Prospective Studies
Regression Analysis
eng
60_published
true
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
University of Lausanne
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