serval:BIB_69F33CAB52E5
Normal values for pancreatic stone protein in different age groups.
10.1186/s12871-015-0149-y
000365587300002
26588901
Schlapbach
L.J.
author
Giannoni
E.
author
Wellmann
S.
author
Stocker
M.
author
Ammann
R.A.
author
Graf
R.
author
article
2015
Bmc Anesthesiology
1471-2253
1471-2253
journal
15
168
BACKGROUND: Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. However, data on population-based reference values are lacking. This study aimed to establish age-specific reference values for PSP.
METHODS: PSP was determined using a specific ELISA. PSP serum concentrations were determined in 372 healthy subjects including 217 neonates, 94 infants and children up to 16 years, and 61 adults. The adjacent categories method was used to determine which age categories had significantly different PSP concentrations.
RESULTS: PSP circulating levels were not gender-dependent and ranged from 1.0 to 99.4 ng/ml with a median of 9.2 ng/ml. PSP increased significantly between the age categories, from a median of 2.6 ng/ml in very preterm newborns, to 6.3 ng/ml in term newborns, to 16.1 ng/ml in older children (p < 0.001). PSP levels were higher on postnatal day three compared to levels measured immediately post delivery (p < 0.001). Paired umbilical artery and umbilical vein samples were strongly correlated (p < 0.001). Simultaneously obtained capillary heel-prick versus venous samples showed a good level of agreement for PSP (Rho 0.89, bias 19 %).
CONCLUSIONS: This study provides age-specific normal values that may be used to define cut-offs for future trials on PSP. We demonstrate an age-dependent increase of PSP from birth to childhood.
Adolescent
Adult
Age Factors
Biomarkers/blood
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant
Infant, Newborn
Lithostathine/blood
Male
Middle Aged
Reference Values
Young Adult
eng
60_published
true
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
University of Lausanne
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