serval:BIB_682279AC2A27
Eosinophilic aseptic arachnoiditis. A neurological complication in HIV-negative drug-addicts.
10.1007/s00415-002-0754-9
000177159700015
12140673
Rossetti
A.O.
author
Meagher-Villemure
K.
author
Vingerhoets
F.
author
Maeder
P.
author
Bogousslavsky
J.
author
article
casereport
2002
Journal of neurology
0340-5354
journal
249
7
884-7
The finding of an eosinophilic aseptic meningitis in IV drug abuse is usually suggestive of an opportunistic infection or an allergic reaction. However, HIV-negative patients are at lower risk for developing these complications. Two young HIV-negative patients, with previous intravenous polytoxicomany, developed cystic arachnoiditis over the spinal cord associated with eosinophilic meningitis. Histology of the meningeal spinal cord lesions revealed a vasculocentric mixed inflammatory reaction. In one patient prednisone led to marked clinical improvement. Since infection, vasculitis, sarcoidosis and previous myelography were ruled out, we believe that the syndrome of eosinophilic aseptic arachnoiditis may be related to an hyperergic reaction in the meniges toward drug-adulterants inoculated through the intravenous route.
Adult
Anti-Inflammatory Agents
Arachnoiditis
Eosinophilia
Female
Humans
Male
Prednisone
Substance Abuse, Intravenous
Syndrome
Treatment Outcome
eng
60_published
true
peer-reviewed
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
University of Lausanne
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