serval:BIB_63158D24E889
Cell therapies for skin regeneration: an overview of 40 years of experience in burn units.
10.4414/smw.2019.20079
000468359400002
31104308
Abdel-Sayed
P.
author
Michetti
M.
author
Scaletta
C.
author
Flahaut
M.
author
Hirt-Burri
N.
author
de Buys Roessingh
A.
author
Raffoul
W.
author
Applegate
L.A.
author
article
review
2019-05-06
Swiss medical weekly
1424-3997
0036-7672
journal
149
w20079
The earliest attempts at cell therapy can be attributed to Charles-Edward Brown-Séquard (1817–1894), who sought to treat senescence and aging by injecting animal gonad shreds into his contemporaries, a practice that was widespread in late 19th century. Since then, advances in science have enabled the development of biological substitutes to restore the function of various tissues. Skin was one of the first tissues to be regenerated. For severe burns, patient survival depends on the restoration of skin function as a barrier against pathogens and control of body temperature and fluid loss. We aim here to overview the different cell therapy techniques implemented at the University Hospital of Lausanne (CHUV), one of the two Swiss national centres of highly specialised medicine for burn care. In particular, we will describe the specific indications for each of the different therapies as well as future perspectives.
Burn Units
Burns/therapy
Cell- and Tissue-Based Therapy/methods
Hospitals, University
Humans
Regeneration
Skin/physiopathology
Skin Transplantation/methods
Switzerland
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Review
Publication Status: epublish
University of Lausanne
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