serval:BIB_6265893B0A91
Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis.
10.1007/s00296-010-1542-y
000280242100011
20512336
Rizzoli
Ren
author
Laroche
Michel
author
Krieg
Marc-Antoine
author
Frieling
Isolde
author
Thomas
Thierry
author
Delmas
Pierre
author
Felsenberg
Dieter
author
article
2010
Rheumatology International
1437-160X[electronic], 0172-8172[linking]
journal
30
10
1341-1348
The structural basis of the antifracture efficacy of strontium ranelate and alendronate is incompletely understood. We compared the effects of strontium ranelate and alendronate on distal tibia microstructure over 2 years using HR-pQCT. In this pre-planned, interim, intention-to-treat analysis at 12 months, 88 osteoporotic postmenopausal women (mean age 63.7 +/- 7.4) were randomized to strontium ranelate 2 g/day or alendronate 70 mg/week in a double-placebo design. Primary endpoints were changes in microstructure. Secondary endpoints included lumbar and hip areal bone mineral density (aBMD), and bone turnover markers. This trial is registered with http://www.controlled-trials.com, number ISRCTN82719233. Baseline characteristics of the two groups were similar. Treatment with strontium ranelate was associated with increases in mean cortical thickness (CTh, 5.3%), cortical area (4.9%) and trabecular density (2.1%) (all P < 0.001, except cortical area P = 0.013). No significant changes were observed with alendronate. Between-group differences in favor of strontium ranelate were observed for CTh, cortical area, BV/TV and trabecular density (P = 0.045, 0.041, 0.048 and 0.035, respectively). aBMD increased to a similar extent with strontium ranelate and alendronate at the spine (5.7% versus 5.1%, respectively) and total hip (3.3% versus 2.2%, respectively). No significant changes were observed in remodeling markers with strontium ranelate, while suppression was observed with alendronate. Within the methodological constraints of HR-pQCT through its possible sensitivity to X-ray attenuation of different minerals, strontium ranelate had greater effects than alendronate on distal tibia cortical thickness and trabecular volumetric density.
quantitative computed-tomography
trabecular bone
postmenopausal osteoporosis
mineral density
mechanisms
strength
fractures
risk
microarchitecture
bisphosphonates
eng
60_published
true
University of Lausanne
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