serval:BIB_619F9E06C1EC
How to assess prognosis after cardiac arrest and therapeutic hypothermia.
10.1186/cc13696
000338991900016
24417885
Taccone
F.
author
Cronberg
T.
author
Friberg
H.
author
Greer
D.
author
Horn
J.
author
Oddo
M.
author
Scolletta
S.
author
Vincent
J.L.
author
article
2014
Critical Care
1466-609X
1364-8535
journal
18
1
202
The prognosis of patients who are admitted in a comatose state following successful resuscitation after cardiac arrest remains uncertain. Although the introduction of therapeutic hypothermia (TH) and improvements in post-resuscitation care have significantly increased the number of patients who are discharged home with minimal brain damage, short-term assessment of neurological outcome remains a challenge. The need for early and accurate prognostic predictors is crucial, especially since sedation and TH may alter the neurological examination and delay the recovery of motor response for several days. The development of additional tools, including electrophysiological examinations (electroencephalography and somatosensory evoked potentials), neuroimaging and chemical biomarkers, may help to evaluate the extent of brain injury in these patients. Given the extensive literature existing on this topic and the confounding effects of TH on the strength of these tools in outcome prognostication after cardiac arrest, the aim of this narrative review is to provide a practical approach to post-anoxic brain injury when TH is used. We also discuss when and how these tools could be combined with the neurological examination in a multimodal approach to improve outcome prediction in this population.
eng
60_published
true
peer-reviewed
Publication types: Journal Article, pdf :Review
University of Lausanne
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