serval:BIB_61413D23E213
Networks of blood proteins in the neuroimmunology of schizophrenia.
10.1038/s41398-018-0158-y
000434722800001
29875399
Jeffries
C.D.
author
Perkins
D.O.
author
Fournier
M.
author
Do
K.Q.
author
Cuenod
M.
author
Khadimallah
I.
author
Domenici
E.
author
Addington
J.
author
Bearden
C.E.
author
Cadenhead
K.S.
author
Cannon
T.D.
author
Cornblatt
B.A.
author
Mathalon
D.H.
author
McGlashan
T.H.
author
Seidman
L.J.
author
Tsuang
M.
author
Walker
E.F.
author
Woods
S.W.
author
article
2018-06-06
Translational psychiatry
2158-3188
2158-3188
journal
8
1
112
Levels of certain circulating cytokines and related immune system molecules are consistently altered in schizophrenia and related disorders. In addition to absolute analyte levels, we sought analytes in correlation networks that could be prognostic. We analyzed baseline blood plasma samples with a Luminex platform from 72 subjects meeting criteria for a psychosis clinical high-risk syndrome; 32 subjects converted to a diagnosis of psychotic disorder within two years while 40 other subjects did not. Another comparison group included 35 unaffected subjects. Assays of 141 analytes passed early quality control. We then used an unweighted co-expression network analysis to identify highly correlated modules in each group. Overall, there was a striking loss of network complexity going from unaffected subjects to nonconverters and thence to converters (applying standard, graph-theoretic metrics). Graph differences were largely driven by proteins regulating tissue remodeling (e.g. blood-brain barrier). In more detail, certain sets of antithetical proteins were highly correlated in unaffected subjects (e.g. SERPINE1 vs MMP9), as expected in homeostasis. However, for particular protein pairs this trend was reversed in converters (e.g. SERPINE1 vs TIMP1, being synthetical inhibitors of remodeling of extracellular matrix and vasculature). Thus, some correlation signals strongly predict impending conversion to a psychotic disorder and directly suggest pharmaceutical targets.
Adolescent
Adult
Biomarkers/blood
Blood Proteins/analysis
Female
Humans
Longitudinal Studies
Male
Matrix Metalloproteinase 9/blood
Neuroimmunomodulation
Plasminogen Activator Inhibitor 1/blood
Schizophrenia/blood
Schizophrenia/diagnosis
Schizophrenia/immunology
Tissue Inhibitor of Metalloproteinase-1/blood
Young Adult
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Multicenter Study ; Observational Study
Publication Status: epublish
University of Lausanne
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