serval:BIB_5E5CD9550AD3
Bioinformatics and HIV Latency.
10.1007/s11904-014-0240-x
000351307700011
25586146
Ciuffi
A.
author
Mohammadi
P.
author
Golumbeanu
M.
author
di Iulio
J.
author
Telenti
A.
author
article
review
2015
Current Hiv/aids Reports
1548-3576
1548-3568
journal
12
1
97-106
Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan. Resting cells do not produce viral particles and are protected from viral-induced cytotoxicity or immune killing. However, these latently infected cells can be reactivated by stochastic events or by external stimuli. The present review focuses on novel genome-wide technologies applied to the study of integration, transcriptome, and proteome characteristics and their recent contribution to the understanding of HIV latency.
eng
60_published
true
peer-reviewed
University of Lausanne
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